000063043 001__ 63043
000063043 005__ 20190709135519.0
000063043 0247_ $$2doi$$a10.3389/fcimb.2017.00114
000063043 0248_ $$2sideral$$a101731
000063043 037__ $$aART-2017-101731
000063043 041__ $$aeng
000063043 100__ $$ade la Fuente, J.
000063043 245__ $$aTick-Pathogen Interactions and Vector Competence: Identification of Molecular Drivers for Tick-Borne Diseases
000063043 260__ $$c2017
000063043 5060_ $$aAccess copy available to the general public$$fUnrestricted
000063043 5203_ $$aTicks and the pathogens they transmit constitute a growing burden for human and animal health worldwide. Vector competence is a component of vectorial capacity and depends on genetic determinants affecting the ability of a vector to transmit a pathogen. These determinants affect traits such as tick-host-pathogen and susceptibility to pathogen infection. Therefore, the elucidation of the mechanisms involved in tick-pathogen interactions that affect vector competence is essential for the identification of molecular drivers for tick-borne diseases. In this review, we provide a comprehensive overview of tick-pathogen molecular interactions for bacteria, viruses, and protozoa affecting human and animal health. Additionally, the impact of tick microbiome on these interactions was considered. Results show that different pathogens evolved similar strategies such as manipulation of the immune response to infect vectors and facilitate multiplication and transmission. Furthermore, some of these strategies may be used by pathogens to infect both tick and mammalian hosts. Identification of interactions that promote tick survival, spread, and pathogen transmission provides the opportunity to disrupt these interactions and lead to a reduction in tick burden and the prevalence of tick-borne diseases. Targeting some of the similar mechanisms used by the pathogens for infection and transmission by ticks may assist in development of preventative strategies against multiple tick-borne diseases.
000063043 536__ $$9info:eu-repo/grantAgreement/ES/MINECO/BFU2016-79892-P$$9info:eu-repo/grantAgreement/EC/FP7/278976/EU/ANTIcipating the Global Onset of Novel Epidemics/ANTIGONE
000063043 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000063043 590__ $$a3.52$$b2017
000063043 591__ $$aMICROBIOLOGY$$b40 / 125 = 0.32$$c2017$$dQ2$$eT1
000063043 591__ $$aIMMUNOLOGY$$b64 / 155 = 0.413$$c2017$$dQ2$$eT2
000063043 592__ $$a1.703$$b2017
000063043 593__ $$aMedicine (miscellaneous)$$c2017$$dQ1
000063043 593__ $$aInfectious Diseases$$c2017$$dQ1
000063043 593__ $$aMicrobiology (medical)$$c2017$$dQ1
000063043 593__ $$aMicrobiology$$c2017$$dQ1
000063043 593__ $$aImmunology$$c2017$$dQ2
000063043 655_4 $$ainfo:eu-repo/semantics/review$$vinfo:eu-repo/semantics/publishedVersion
000063043 700__ $$aAntunes, S.
000063043 700__ $$aBonnet, S.
000063043 700__ $$aCabezas-Cruz, A.
000063043 700__ $$aDomingos, A.G.
000063043 700__ $$0(orcid)0000-0001-7483-046X$$aEstrada-Peña, A.$$uUniversidad de Zaragoza
000063043 700__ $$aJohnson, N.
000063043 700__ $$aKocan, K.M.
000063043 700__ $$aMansfield, K.L.
000063043 700__ $$aNijhof, A.M.
000063043 700__ $$aPapa, A.
000063043 700__ $$aRudenko, N.
000063043 700__ $$aVillar, M.
000063043 700__ $$aAlberdi, P.
000063043 700__ $$aTorina, A.
000063043 700__ $$aAyllón, N.
000063043 700__ $$aVancova, M.
000063043 700__ $$aGolovchenko, M.
000063043 700__ $$aGrubhoffer, L.
000063043 700__ $$aCaracappa, S.
000063043 700__ $$aFooks, A.R.
000063043 700__ $$aGortazar, C.
000063043 700__ $$aRego, R.O.M.
000063043 7102_ $$11009$$2773$$aUniversidad de Zaragoza$$bDpto. Patología Animal$$cÁrea Sanidad Animal
000063043 773__ $$g7 (2017), 114 [13 pp]$$tFrontiers in cellular and infection microbiology$$x2235-2988
000063043 8564_ $$s1963174$$uhttps://zaguan.unizar.es/record/63043/files/texto_completo.pdf$$yVersión publicada
000063043 8564_ $$s11901$$uhttps://zaguan.unizar.es/record/63043/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000063043 909CO $$ooai:zaguan.unizar.es:63043$$particulos$$pdriver
000063043 951__ $$a2019-07-09-11:56:44
000063043 980__ $$aARTICLE