000063104 001__ 63104
000063104 005__ 20181123104100.0
000063104 0247_ $$2doi$$a10.1109/CIC.2015.7411043
000063104 0248_ $$2sideral$$a94688
000063104 037__ $$aART-2016-94688
000063104 041__ $$aeng
000063104 100__ $$0(orcid)0000-0003-0226-4950$$aMartín-Yebra, Alba
000063104 245__ $$aCircadian modulation on T-wave alternans activity in chronic heart failure patients
000063104 260__ $$c2016
000063104 5060_ $$aAccess copy available to the general public$$fUnrestricted
000063104 5203_ $$aAverage TWA activity has been shown to be an independent predictor of sudden cardiac death (SCD) in chronic heart failure (CHF) patients. However, the influence of circadian rhythms on TWA remains understudied. In this work, we assessed circadian TWA changes in a CHF population and evaluated whether the prognostic value of TWA indices is sensitive to the circadian pattern. Holter ECG recordings from 626 consecutive CHF patients (52 SCD) were analyzed. The index of average alternans (IAA), quantifying the average TWA level, was measured in 4 consecutive 6-hour intervals using a multilead fully-automated method. Survival analysis was performed considering SCD as an independent endpoint. IAA changed along the day, with statistically significant lower values during the night than during daytime. This pattern is similar to the one observed in the mean heart rate (HR). However, a low correlation (r=.18) was found between IAA and HR in windows of 128 beats. After dichotomization of patients based on the third quartile of IAA indices, IAA indices computed between hours 06-12 (IAA06-12) and 18-24 (IAA18-24) successfully predicted SCD (Hazard Ratio, HaR:2.34(1.33-4.13)per µV, andHaR:1.87(1.04-3.36) per µV, respectively). In conclusion, circadian variation should be considered for SCD risk prediction.
000063104 536__ $$9info:eu-repo/grantAgreement/ES/DGA/T96$$9info:eu-repo/grantAgreement/ES/MINECO/TEC2013-42140-R
000063104 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000063104 655_4 $$ainfo:eu-repo/semantics/conferenceObject$$vinfo:eu-repo/semantics/publishedVersion
000063104 700__ $$aCaiani, Enrico G.
000063104 700__ $$0(orcid)0000-0003-3434-9254$$aLaguna, Pablo$$uUniversidad de Zaragoza
000063104 700__ $$aMonasterio, Violeta
000063104 700__ $$0(orcid)0000-0002-7503-3339$$aMartínez, Juan Pablo$$uUniversidad de Zaragoza
000063104 7102_ $$15008$$2800$$aUniversidad de Zaragoza$$bDpto. Ingeniería Electrón.Com.$$cÁrea Teoría Señal y Comunicac.
000063104 773__ $$g42 (2016), 845-848$$pComput. cardiol.$$tComputing in Cardiology$$x2325-8861
000063104 8564_ $$s634384$$uhttps://zaguan.unizar.es/record/63104/files/texto_completo.pdf$$yVersión publicada
000063104 8564_ $$s108049$$uhttps://zaguan.unizar.es/record/63104/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000063104 909CO $$ooai:zaguan.unizar.es:63104$$particulos$$pdriver
000063104 951__ $$a2018-11-23-10:32:51
000063104 980__ $$aARTICLE