000063210 001__ 63210
000063210 005__ 20190709135520.0
000063210 0247_ $$2doi$$a10.1186/s12931-017-0658-y
000063210 0248_ $$2sideral$$a101960
000063210 037__ $$aART-2017-101960
000063210 041__ $$aeng
000063210 100__ $$aZagaceta, J.
000063210 245__ $$aProspective comparison of non-invasive risk markers of major cardiovascular events in COPD patients
000063210 260__ $$c2017
000063210 5060_ $$aAccess copy available to the general public$$fUnrestricted
000063210 5203_ $$aBackground: Chronic Obstructive Pulmonary Disease (COPD) is an independent risk factor for cardiovascular (CV) disease, one of the most frequent causes of death in COPD patients. The goal of the present study was to evaluate the prognostic value of non-invasive CV risk markers in COPD patients. Methods: CV risk was prospectively evaluated in 287 COPD patients using non-invasive markers including the Framingham score, the Systematic Coronary Risk Evaluation (SCORE) charts, coronary arterial calcium (CAC), epicardial adipose tissue (EAT), as well as clinical, biochemical and physiological variables. The predictive power of each parameter was explored using CV events as the main outcome. Results: During a median follow up of 65 months (ICR: 36-100), 44 CV events were recorded, 12 acute myocardial infarctions (27.3%), 10 ischemic heart disease/angina (22.7%), 12 peripheral artery disease events requiring surgery (27.3%) and 10 strokes (22.7%). A total of 35 CV deaths occurred during that period. Univariable analysis determined that age, hypertension, CRP, total Cholesterol, LDL-Cholesterol, Framingham score and CAC were independently associated with CV events. Multivariable analysis identified CAC as the best predictor of CV events (HR; 95%CI: 1.32; 1.19-1.46, p < 001). Conclusions: In COPD patients attending pulmonary clinics, CAC was the best independent non-invasive predictor of CV events. This tool may help evaluate the risk for a CV event in patients with COPD. Larger studies should reproduce and validate these findings.
000063210 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000063210 590__ $$a3.751$$b2017
000063210 591__ $$aRESPIRATORY SYSTEM$$b16 / 59 = 0.271$$c2017$$dQ2$$eT1
000063210 592__ $$a1.644$$b2017
000063210 593__ $$aPulmonary and Respiratory Medicine$$c2017$$dQ1
000063210 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000063210 700__ $$aBastarrika, G.
000063210 700__ $$aZulueta, J.J.
000063210 700__ $$aColina, I.
000063210 700__ $$aAlcaide, A.B.
000063210 700__ $$aCampo, A.
000063210 700__ $$aDivo, M.
000063210 700__ $$aCasanova, C.
000063210 700__ $$0(orcid)0000-0001-9096-2294$$aMarin, J.M.$$uUniversidad de Zaragoza
000063210 700__ $$aPinto-Plata, V.M.
000063210 700__ $$aCelli, B.R.
000063210 700__ $$ade-Torres, J.P.
000063210 7102_ $$11007$$2610$$aUniversidad de Zaragoza$$bDpto. Medicina, Psiqu. y Derm.$$cArea Medicina
000063210 773__ $$g18, 175 (2017), [7 pp]$$pRespir. res.$$tRESPIRATORY RESEARCH$$x1465-9921
000063210 8564_ $$s475544$$uhttps://zaguan.unizar.es/record/63210/files/texto_completo.pdf$$yVersión publicada
000063210 8564_ $$s97532$$uhttps://zaguan.unizar.es/record/63210/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000063210 909CO $$ooai:zaguan.unizar.es:63210$$particulos$$pdriver
000063210 951__ $$a2019-07-09-11:57:09
000063210 980__ $$aARTICLE