000063229 001__ 63229 000063229 005__ 20201105083207.0 000063229 0247_ $$2doi$$a10.1136/bmjopen-2016-013215 000063229 0248_ $$2sideral$$a98449 000063229 037__ $$aART-2017-98449 000063229 041__ $$aeng 000063229 100__ $$aBrugulat-Serrat, A. 000063229 245__ $$aIncidental findings on brain MRI of cognitively normal first-degree descendants of patients with Alzheimer's disease: A cross-sectional analysis from the ALFA (Alzheimer and Families) project 000063229 260__ $$c2017 000063229 5060_ $$aAccess copy available to the general public$$fUnrestricted 000063229 5203_ $$aObjectives To describe the prevalence of brain MRI incidental findings (IF) in a cohort of cognitively normal first-degree descendants of patients with Alzheimer''s disease (AD). Design Cross-sectional observational study. Setting All scans were obtained with a 3.0 s€...T scanner. Scans were evaluated by a single neuroradiologist and IF recorded and categorised. The presence of white matter hyperintensities (WMH) was determined with the Fazekas scale and reported as relevant if =2. Participants 575 participants (45-75s €...years) underwent high-resolution structural brain MRI. Participants were cognitively normal and scored over the respective cut-off values in all the following neuropsychological tests: Mini-Mental State Examination (=26), Memory Impairment Screen (=6), Time Orientation Subtest of the Barcelona Test II (=68), verbal semantic fluency (naming animals =12). Clinical Dementia Rating (CDR) had to be 0. Results 155 participants (27.0%) presented with at least one IF. Relevant WMH were present in 7.8% of the participants, and vascular abnormalities, cyst and brain volume loss in 10.7%, 3.1% and 6.9% of the study volunteers, respectively. Neoplastic brain findings were found in 2.4% of participants and within these, meningiomas were the most common (1.7%) and more frequently found in women. A positive correlation between increasing age and the presence of IF was found. Additionally, brain atrophy greater than that expected by age was significantly more prevalent in participants without a parental history of AD. Conclusions Brain MRIs of healthy middle-aged participants show a relatively high prevalence of IF even when study participants have been screened for subtle cognitive alterations. Most of our participants are first-degree descendants of patients with AD, and therefore these results are of special relevance for novel imaging studies in the context of AD prevention in cognitively healthy middle-aged participants. Trial registration number NCT02198586. 000063229 536__ $$9info:eu-repo/grantAgreement/ES/ISCIII/PI12-00326$$9info:eu-repo/grantAgreement/ES/MINECO/RYC-2013-13054 000063229 540__ $$9info:eu-repo/semantics/openAccess$$aby-nc$$uhttp://creativecommons.org/licenses/by-nc/3.0/es/ 000063229 590__ $$a2.413$$b2017 000063229 591__ $$aMEDICINE, GENERAL & INTERNAL$$b43 / 154 = 0.279$$c2017$$dQ2$$eT1 000063229 592__ $$a1.372$$b2017 000063229 593__ $$aMedicine (miscellaneous)$$c2017$$dQ1 000063229 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion 000063229 700__ $$aRojas, S. 000063229 700__ $$aBargalló, N. 000063229 700__ $$aConesa, G. 000063229 700__ $$aMinguillón, C. 000063229 700__ $$aFauria, K. 000063229 700__ $$aGramunt, N. 000063229 700__ $$aMolinuevo, J. L. 000063229 700__ $$aGispert, J. D. 000063229 773__ $$g7, 3 (2017), [10 pp.]$$pBMJ Open$$tBMJ open$$x2044-6055 000063229 8564_ $$s1050127$$uhttps://zaguan.unizar.es/record/63229/files/texto_completo.pdf$$yVersión publicada 000063229 8564_ $$s44432$$uhttps://zaguan.unizar.es/record/63229/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada 000063229 909CO $$ooai:zaguan.unizar.es:63229$$particulos$$pdriver 000063229 951__ $$a2020-11-05-08:19:23 000063229 980__ $$aARTICLE