Incidental findings on brain MRI of cognitively normal first-degree descendants of patients with Alzheimer's disease: A cross-sectional analysis from the ALFA (Alzheimer and Families) project
Brugulat-Serrat, A. ; Rojas, S. ; Bargalló, N. ; Conesa, G. ; Minguillón, C. ; Fauria, K. ; Gramunt, N. ; Molinuevo, J. L. ; Gispert, J. D.
Resumen: Objectives To describe the prevalence of brain MRI incidental findings (IF) in a cohort of cognitively normal first-degree descendants of patients with Alzheimer''s disease (AD). Design Cross-sectional observational study. Setting All scans were obtained with a 3.0 s€...T scanner. Scans were evaluated by a single neuroradiologist and IF recorded and categorised. The presence of white matter hyperintensities (WMH) was determined with the Fazekas scale and reported as relevant if =2. Participants 575 participants (45-75s €...years) underwent high-resolution structural brain MRI. Participants were cognitively normal and scored over the respective cut-off values in all the following neuropsychological tests: Mini-Mental State Examination (=26), Memory Impairment Screen (=6), Time Orientation Subtest of the Barcelona Test II (=68), verbal semantic fluency (naming animals =12). Clinical Dementia Rating (CDR) had to be 0. Results 155 participants (27.0%) presented with at least one IF. Relevant WMH were present in 7.8% of the participants, and vascular abnormalities, cyst and brain volume loss in 10.7%, 3.1% and 6.9% of the study volunteers, respectively. Neoplastic brain findings were found in 2.4% of participants and within these, meningiomas were the most common (1.7%) and more frequently found in women. A positive correlation between increasing age and the presence of IF was found. Additionally, brain atrophy greater than that expected by age was significantly more prevalent in participants without a parental history of AD. Conclusions Brain MRIs of healthy middle-aged participants show a relatively high prevalence of IF even when study participants have been screened for subtle cognitive alterations. Most of our participants are first-degree descendants of patients with AD, and therefore these results are of special relevance for novel imaging studies in the context of AD prevention in cognitively healthy middle-aged participants. Trial registration number NCT02198586.
Idioma: Inglés
DOI: 10.1136/bmjopen-2016-013215
Año: 2017
Publicado en: BMJ open 7, 3 (2017), [10 pp.]
ISSN: 2044-6055
Factor impacto JCR: 2.413 (2017)
Categ. JCR: MEDICINE, GENERAL & INTERNAL rank: 43 / 154 = 0.279 (2017) - Q2 - T1
Factor impacto SCIMAGO: 1.372 - Medicine (miscellaneous) (Q1)
Financiación: info:eu-repo/grantAgreement/ES/ISCIII/PI12-00326
Financiación: info:eu-repo/grantAgreement/ES/MINECO/RYC-2013-13054
Tipo y forma: Article (Published version)
You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use. You may not use the material for commercial purposes.
Exportado de SIDERAL (2020-11-05-08:19:23)
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Idioma: Inglés
DOI: 10.1136/bmjopen-2016-013215
Año: 2017
Publicado en: BMJ open 7, 3 (2017), [10 pp.]
ISSN: 2044-6055
Factor impacto JCR: 2.413 (2017)
Categ. JCR: MEDICINE, GENERAL & INTERNAL rank: 43 / 154 = 0.279 (2017) - Q2 - T1
Factor impacto SCIMAGO: 1.372 - Medicine (miscellaneous) (Q1)
Financiación: info:eu-repo/grantAgreement/ES/ISCIII/PI12-00326
Financiación: info:eu-repo/grantAgreement/ES/MINECO/RYC-2013-13054
Tipo y forma: Article (Published version)
You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use. You may not use the material for commercial purposes. Exportado de SIDERAL (2020-11-05-08:19:23)
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