000063284 001__ 63284
000063284 005__ 20190709135445.0
000063284 0247_ $$2doi$$a10.1039/c6ja00374e
000063284 0248_ $$2sideral$$a97842
000063284 037__ $$aART-2017-97842
000063284 041__ $$aeng
000063284 100__ $$aCañabate, Águeda
000063284 245__ $$aAnalysis of whole blood by ICP-MS equipped with a high temperature total sample consumption system
000063284 260__ $$c2017
000063284 5060_ $$aAccess copy available to the general public$$fUnrestricted
000063284 5203_ $$aIn this work, the performance of a high temperature torch Integrated Sample Introduction System (hTISIS) using inductively coupled plasma mass spectrometry (ICP-MS) for the multi-element analysis of whole blood is evaluated. Two different quadrupole-based spectrometers were tested and the optimization studies were performed with a reference whole blood material. Sample dilution factor and hTISIS temperature were taken as the variables. The sample was introduced following two different procedures: continuous aspiration and air-segmentation. The optimum performance of the system in terms of both analytical figures of merit and accuracy was obtained for a hTISIS temperature of 200 °C and for either 1 : 10 or 1 : 25 dilution factors depending on the ICP-MS device used. An improvement in terms of sensitivity and detection limits was obtained with the hTISIS as compared to the conventional cyclonic spray chamber. Thus, for 1 : 25 diluted blood samples, the hTISIS improved the sensitivity by a factor ranging 2.0-4.5. Moreover, at 200 °C, the limits of detection for hTISIS at 200 °C were 1.1 to 8.4 times lower than those for the cyclonic spray chamber. This analytical parameter was in the ng L-1 range for the detected elements. Matrix effects in turn became less severe as the hTISIS temperature increased (from room temperature to 80 °C). All these results were obtained without a severe degradation of the fundamental plasma parameters. In fact, under optimum conditions BaO+/Ba+ and Ba2+/Ba+ signal ratios were 1.2% and 2.0%, respectively. The developed method was applied for the analysis of low volumes (ca. 2.5 µL) of real blood samples after a minimally invasive collection by volumetric absorptive microsampling. The hTISIS is an easy-to-implement sample introduction system that can be employed for the routine analysis using ICP-MS.
000063284 536__ $$9info:eu-repo/grantAgreement/ES/MINECO/CTQ2015-64684-P
000063284 540__ $$9info:eu-repo/semantics/openAccess$$aAll rights reserved$$uhttp://www.europeana.eu/rights/rr-f/
000063284 590__ $$a3.608$$b2017
000063284 591__ $$aSPECTROSCOPY$$b4 / 42 = 0.095$$c2017$$dQ1$$eT1
000063284 591__ $$aCHEMISTRY, ANALYTICAL$$b13 / 80 = 0.162$$c2017$$dQ1$$eT1
000063284 592__ $$a1.066$$b2017
000063284 593__ $$aSpectroscopy$$c2017$$dQ1
000063284 593__ $$aAnalytical Chemistry$$c2017$$dQ1
000063284 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/acceptedVersion
000063284 700__ $$0(orcid)0000-0003-2640-8496$$aGarcía-Ruiz, Esperanza$$uUniversidad de Zaragoza
000063284 700__ $$0(orcid)0000-0002-7450-8769$$aResano, Martín$$uUniversidad de Zaragoza
000063284 700__ $$aTodolí, José Luis
000063284 7102_ $$12009$$2750$$aUniversidad de Zaragoza$$bDpto. Química Analítica$$cÁrea Química Analítica
000063284 773__ $$g32, 1 (2017), 78-87 [38 pp.]$$pJ. anal. at. spectrom.$$tJournal of Analytical Atomic Spectrometry$$x0267-9477
000063284 8564_ $$s241929$$uhttps://zaguan.unizar.es/record/63284/files/texto_completo.pdf$$yPostprint
000063284 8564_ $$s28166$$uhttps://zaguan.unizar.es/record/63284/files/texto_completo.jpg?subformat=icon$$xicon$$yPostprint
000063284 909CO $$ooai:zaguan.unizar.es:63284$$particulos$$pdriver
000063284 951__ $$a2019-07-09-11:37:59
000063284 980__ $$aARTICLE