000063288 001__ 63288
000063288 005__ 20171129112116.0
000063288 0247_ $$2doi$$a10.1371/journal.pone.0094318
000063288 0248_ $$2sideral$$a100138
000063288 037__ $$aART-2014-100138
000063288 041__ $$aeng
000063288 100__ $$aLorente, L.
000063288 245__ $$aAssociation of sepsis-related mortality with early increase of TIMP-1/MMP-9 ratio
000063288 260__ $$c2014
000063288 5060_ $$aAccess copy available to the general public$$fUnrestricted
000063288 5203_ $$aObjective: Higher circulating levels of tissue inhibitor of matrix metalloproteinases (TIMP)-1 at the time of severe sepsis diagnosis have been reported in nonsurviving than in surviving patients. However, the following questions remain unanswered: 1) Does TIMP-1/MMP-9 ratio differ throughout the first week of intensive care between surviving and nonsurviving patients? 2) Is there an association between TIMP-1/MMP-9 ratio and sepsis severity and mortality during such period? 3) Could TIMP-1/MMP-9 ratio during the first week be used as an early biomarker of sepsis outcome? 4) Is there an association between TIMP-1/MMP-9 ratio and coagulation state and circulating cytokine levels during the first week of intensive care in these patients? The present study sought to answer these questions. Methods: Multicenter, observational and prospective study carried out in six Spanish Intensive Care Units (ICUs) of 295 patients with severe sepsis. Were measured circulating levels of TIMP-1, MMP-9, tumour necrosis factor (TNF)-alpha, interleukin (IL)-10 and plasminogen activator inhibitor (PAI)-1 at day 1, 4 and 8. End-point was 30-day mortality. Results: We found higher TIMP-1/MMP-9 ratio during the first week in non-surviving (n = 98) than in surviving patients (n = 197) (p, 0.01). Logistic regression analyses showed that TIMP-1/MMP-9 ratio at days 1, 4 and 8 was associated with mortality. Receiver operating characteristic (ROC) curves showed that TIMP-1/MMP-9 ratio at days 1, 4 and 8 could predict mortality. There was an association between TIMP-1/MMP-9 ratio and TNF-alpha, IL-10, PAI-1 and lactic acid levels, SOFA score and platelet count at days 1, 4 and 8. Conclusions: The novel findings of our study were that non-surviving septic patients showed persistently higher TIMP-1/ MMP-9 ratio than survivors ones during the first week, which was associated with severity, coagulation state, circulating cytokine levels and mortality; thus representing a new biomarker of sepsis outcome.
000063288 536__ $$9info:eu-repo/grantAgreement/ES/ISCIII/FIS/PI10-01572$$9info:eu-repo/grantAgreement/ES/ISCIII/I3SNS-INT-11-063$$9info:eu-repo/grantAgreement/ES/ISCIII/I3SNS-INT-12-087
000063288 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000063288 590__ $$a3.234$$b2014
000063288 591__ $$aMULTIDISCIPLINARY SCIENCES$$b9 / 57 = 0.158$$c2014$$dQ1$$eT1
000063288 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000063288 700__ $$aMartín, M. M.
000063288 700__ $$aSolé-Violn, J.
000063288 700__ $$aBlanquer, J.
000063288 700__ $$0(orcid)0000-0002-3312-9383$$aLabarta, L.$$uUniversidad de Zaragoza
000063288 700__ $$aDíaz, C.
000063288 700__ $$aBorreguero-León, J. M.
000063288 700__ $$aOrbe, J.
000063288 700__ $$aRodríguez, J. A.
000063288 700__ $$aJiménez, A.
000063288 700__ $$aPáramo, J. A.
000063288 7102_ $$11007$$2610$$aUniversidad de Zaragoza$$bDepartamento de Medicina, Psiquiatría y Dermatología$$cMedicina
000063288 773__ $$g9, 4 (2014), e94318 [7 pp]$$pPLoS One$$tPLoS One$$x1932-6203
000063288 8564_ $$s258739$$uhttp://zaguan.unizar.es/record/63288/files/texto_completo.pdf$$yVersión publicada
000063288 8564_ $$s124537$$uhttp://zaguan.unizar.es/record/63288/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000063288 909CO $$ooai:zaguan.unizar.es:63288$$particulos$$pdriver
000063288 951__ $$a2017-11-28-12:45:33
000063288 980__ $$aARTICLE