In vitro and in silico characterization of open-cell structures of trabecular bone

Ramos-Infante, Samuel Jesús (Universidad de Zaragoza) ; Pérez Ansón, María de los Ángeles (Universidad de Zaragoza)

Resumen: This work aimed to perform a detailed in vitro and in silico characterization of open-cell structures, which resemble trabecular bone, to elucidate osteoporosis failure mechanisms. Experimental and image-based computational methods were used to estimate Young's modulus and porosities of different open-cell structures (Sawbones; Malmö, Sweden). Three different open-cell structures with different porosities were characterized. Additionally, some open-cell structures were scanned using a microcomputed tomography system (µCT) to non-destructively predict specimen Young's modulus of the structures by developing voxel-based and tetrahedral finite element (FE) models. A 3D reconstruction and FE analyses were used. The experimental and computational results with different element types (linear and quadratic tetrahedrons and voxel-based meshes) were compared with Sawbones data (Sawbones; Malmö, Sweden) revealing important differences in Young's modulus and porosities. The specimens with high and low volume fractions were best represented by linear and quadratic tetrahedrons, respectively. These results could be used to develop new osteoporosis-prevention strategies.

Idioma: Inglés

DOI: 10.1080/10255842.2017.1390086

Año: 2017

Publicado en: Computer methods in biomechanics and biomedical engineering 20, 14 (2017), 1562-1570
ISSN: 1025-5842

Factor impacto JCR: 1.974 (2017)

Categ. JCR: COMPUTER SCIENCE, INTERDISCIPLINARY APPLICATIONS rank: 51 / 105 = 0.486 (2017) - Q2 - T2
Categ. JCR: ENGINEERING, BIOMEDICAL rank: 40 / 78 = 0.513 (2017) - Q3 - T2

Factor impacto SCIMAGO: 0.579 - Bioengineering (Q2) - Biomedical Engineering (Q2) - Medicine (miscellaneous) (Q2) - Human-Computer Interaction (Q2) - Computer Science Applications (Q2)

Financiación: info:eu-repo/grantAgreement/EUR/FP7/ERC2012-StG-306751
Financiación: info:eu-repo/grantAgreement/ES/MINECO/DPI2014-53401-C2-1-R

Tipo y forma: Artículo (Versión definitiva)

Área (Departamento): Proy. investigacion HJA (Dpto. Ingeniería Mecánica)
Área (Departamento): Área Mec.Med.Cont. y Teor.Est. (Dpto. Ingeniería Mecánica)