Resumen: Background: Previous studies have shown that smoking is associated with health-related quality of life (HRQoL) impairment. In order to evaluate HRQoL in a sample of Spanish relapsers, a cross-sectional study was conducted. Method: The sample was made up of 775 smokers who had relapsed after a period of abstinence. HRQoL was evaluated using the Euro-Qol questionnaire (EQ-5D); through the descriptive profile, the EQ-5D index and the visual analogue scale (EQ-VAS). Results: Higher nicotine dependence was related to worse HRQL. According to the EQ-VAS, higher daily cigarette consumption and more years smoking were related to worse perceived health. In the EQ-5D those who had quit smoking in the previous year perceived worse health. Mobility and anxiety/ depression are the dimensions affected by smoking. Those who are more nicotine dependent (OR = 2.29) and have been smoking for longer (OR = 4.12) are more likely to have mobility problems; and those who are nicotine dependent (OR = 1.85) and relapsed more than a year ago (OR = 0.63), are more likely to experience anxiety/ depression. Conclusions: Nicotine dependence demonstrated a determining effect on HRQOL deterioration in smokers who have relapsed. Idioma: Inglés DOI: 10.7334/psicothema2017.61 Año: 2018 Publicado en: PSICOTHEMA 30, 1 (2018), 27-32 ISSN: 0214-9915 Factor impacto JCR: 1.551 (2018) Categ. JCR: PSYCHOLOGY, MULTIDISCIPLINARY rank: 57 / 137 = 0.416 (2018) - Q2 - T2 Factor impacto SCIMAGO: 0.641 - Psychology (miscellaneous) (Q2)