Resumen: Cancer of unknown primary site is a histologically confirmed cancer that manifests in advanced stage, with no identifiable primary site following standard diagnostic procedures. Patients are initially categorized based on the findings of the initial biopsy: adenocarcinoma, squamous-cell carcinoma, neuroendocrine carcinoma, and poorly differentiated carcinoma. Appropriate patient management requires understanding several clinical and pathological features that aid in identifying several subsets of patients with more responsive tumors. Idioma: Inglés DOI: 10.1007/s12094-017-1807-y Año: 2017 Publicado en: Clinical and Translational Oncology 20 (2017), 89 – 96 ISSN: 1699-048X Factor impacto JCR: 2.392 (2017) Categ. JCR: ONCOLOGY rank: 156 / 223 = 0.7 (2017) - Q3 - T3 Factor impacto SCIMAGO: 0.819 - Medicine (miscellaneous) (Q2) - Oncology (Q2) - Cancer Research (Q3)