000065585 001__ 65585
000065585 005__ 20200117212659.0
000065585 0247_ $$2doi$$a10.1016/j.jaci.2017.06.043
000065585 0248_ $$2sideral$$a104245
000065585 037__ $$aART-2018-104245
000065585 041__ $$aeng
000065585 100__ $$aBjörkman, A.
000065585 245__ $$aReduced immunoglobulin gene diversity in patients with Cornelia de Lange syndrome
000065585 260__ $$c2018
000065585 5060_ $$aAccess copy available to the general public$$fUnrestricted
000065585 5203_ $$aTo the Editor: B cells rely on a broad receptor repertoire to provide protection against a wide range of pathogens. This is in part achieved through V(D)J recombination, which, by assembling various combinations of variable (V), diversity (D), and joining (J) genes, creates different IgV regions.1 The recombination processes is initiated by recombination-activating gene (RAG) 1/RAG2 enzymes and requires a functional nonhomologous end-joining (NHEJ) machinery. B cells can further diversify their IgV regions through somatic hypermutation (SHM) to improve affinity between the antibody and antigen and switch the isotype of antibody produced by class-switch recombination (CSR). Both processes are initiated by activation-induced cytidine deaminase (AID) and rely on transcription and a number of DNA repair mechanisms...
000065585 540__ $$9info:eu-repo/semantics/openAccess$$aby-nc-nd$$uhttp://creativecommons.org/licenses/by-nc-nd/3.0/es/
000065585 590__ $$a14.11$$b2018
000065585 591__ $$aIMMUNOLOGY$$b6 / 157 = 0.038$$c2018$$dQ1$$eT1
000065585 591__ $$aALLERGY$$b1 / 27 = 0.037$$c2018$$dQ1$$eT1
000065585 592__ $$a3.702$$b2018
000065585 593__ $$aImmunology and Allergy$$c2018$$dQ1
000065585 593__ $$aImmunology$$c2018$$dQ1
000065585 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000065585 700__ $$aDu, L.
000065585 700__ $$avan der Burg, M.
000065585 700__ $$aCormier-Daire, V.
000065585 700__ $$aBorck, G.
000065585 700__ $$0(orcid)0000-0003-3203-6254$$aPié, J.$$uUniversidad de Zaragoza
000065585 700__ $$aAnderlid, B.-M.
000065585 700__ $$aHammarström, L.
000065585 700__ $$aStröm, L.
000065585 700__ $$ade Villartay, J.-P.
000065585 700__ $$aKipling, D.
000065585 700__ $$aDunn Walters, D.
000065585 700__ $$aPan-Hammarström, Q.
000065585 7102_ $$11005$$2410$$aUniversidad de Zaragoza$$bDpto. Farmacología y Fisiolog.$$cÁrea Fisiología
000065585 773__ $$g141, 1 (2018), 408-411.e8$$pJ. allergy clin. immunol.$$tJournal of allergy and clinical immunology$$x0091-6749
000065585 8564_ $$s219536$$uhttps://zaguan.unizar.es/record/65585/files/texto_completo.pdf$$yVersión publicada
000065585 8564_ $$s147456$$uhttps://zaguan.unizar.es/record/65585/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000065585 909CO $$ooai:zaguan.unizar.es:65585$$particulos$$pdriver
000065585 951__ $$a2020-01-17-21:24:43
000065585 980__ $$aARTICLE