000070700 001__ 70700
000070700 005__ 20180522140725.0
000070700 0247_ $$2doi$$a10.1371/journal.pgen.1003460
000070700 0248_ $$2sideral$$a81858
000070700 037__ $$aART-2013-81858
000070700 041__ $$aeng
000070700 100__ $$aRoewer, L.
000070700 245__ $$aContinent-Wide Decoupling of Y-Chromosomal Genetic Variation from Language and Geography in Native South Americans
000070700 260__ $$c2013
000070700 5060_ $$aAccess copy available to the general public$$fUnrestricted
000070700 5203_ $$aNumerous studies of human populations in Europe and Asia have revealed a concordance between their extant genetic structure and the prevailing regional pattern of geography and language. For native South Americans, however, such evidence has been lacking so far. Therefore, we examined the relationship between Y-chromosomal genotype on the one hand, and male geographic origin and linguistic affiliation on the other, in the largest study of South American natives to date in terms of sampled individuals and populations. A total of 1,011 individuals, representing 50 tribal populations from 81 settlements, were genotyped for up to 17 short tandem repeat (STR) markers and 16 single nucleotide polymorphisms (Y-SNPs), the latter resolving phylogenetic lineages Q and C. Virtually no structure became apparent for the extant Y-chromosomal genetic variation of South American males that could sensibly be related to their inter-tribal geographic and linguistic relationships. This continent-wide decoupling is consistent with a rapid peopling of the continent followed by long periods of isolation in small groups. Furthermore, for the first time, we identified a distinct geographical cluster of Y-SNP lineages C-M217 (C3*) in South America. Such haplotypes are virtually absent from North and Central America, but occur at high frequency in Asia. Together with the locally confined Y-STR autocorrelation observed in our study as a whole, the available data therefore suggest a late introduction of C3* into South America no more than 6,000 years ago, perhaps via coastal or trans-Pacific routes. Extensive simulations revealed that the observed lack of haplogroup C3* among extant North and Central American natives is only compatible with low levels of migration between the ancestor populations of C3* carriers and non-carriers. In summary, our data highlight the fact that a pronounced correlation between genetic and geographic/cultural structure can only be expected under very specific conditions, most of which are likely not to have been met by the ancestors of native South Americans.
000070700 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000070700 590__ $$a8.167$$b2013
000070700 591__ $$aGENETICS & HEREDITY$$b14 / 164 = 0.085$$c2013$$dQ1$$eT1
000070700 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000070700 700__ $$aNothnagel, M.
000070700 700__ $$aGusmão, L.
000070700 700__ $$aGomes, V.
000070700 700__ $$aGonzález, M.
000070700 700__ $$aCorach, D.
000070700 700__ $$aSala, A.
000070700 700__ $$aAlechine, E.
000070700 700__ $$aPalha, T.
000070700 700__ $$aSantos, N.
000070700 700__ $$aRibeiro-dos-Santos, A.
000070700 700__ $$aGeppert, M.
000070700 700__ $$aWilluweit, S.
000070700 700__ $$aNagy, M.
000070700 700__ $$aZweynert, S.
000070700 700__ $$0(orcid)0000-0002-6869-1413$$aBaeta, M.
000070700 700__ $$0(orcid)0000-0001-5643-3970$$aNúñez, C.
000070700 700__ $$0(orcid)0000-0001-6469-9189$$aMartínez-Jarreta, B.$$uUniversidad de Zaragoza
000070700 700__ $$aGonzález-Andrade, F.
000070700 700__ $$aFagundes, de Carvalho
000070700 700__ $$ada Silva, D.A.
000070700 700__ $$aBuiles, J.J.
000070700 700__ $$aTurbón, D.
000070700 700__ $$aLopez Parra, A.M.
000070700 700__ $$aArroyo-Pardo, E.
000070700 700__ $$aToscanini, U.
000070700 700__ $$aBorjas, L.
000070700 700__ $$aBarletta, C.
000070700 700__ $$aEwart, E.
000070700 700__ $$aSantos, S.
000070700 700__ $$aKrawczak, M.
000070700 7102_ $$11000$$2613$$aUniversidad de Zaragoza$$bDepartamento de Anatomía Patológica, Medicina Legal y Forense y Toxicología$$cMedicina Legal y Forense
000070700 773__ $$g9, 4 (2013), e1003460 [16pp]$$pPLoS Genet.$$tPLoS Genetics$$x1553-7390
000070700 8564_ $$s383999$$uhttp://zaguan.unizar.es/record/70700/files/texto_completo.pdf$$yVersión publicada
000070700 8564_ $$s131463$$uhttp://zaguan.unizar.es/record/70700/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000070700 909CO $$ooai:zaguan.unizar.es:70700$$particulos$$pdriver
000070700 951__ $$a2018-05-22-13:32:22
000070700 980__ $$aARTICLE