000074916 001__ 74916
000074916 005__ 20201009175924.0
000074916 0247_ $$2doi$$a10.3390/molecules23061399
000074916 0248_ $$2sideral$$a107234
000074916 037__ $$aART-2018-107234
000074916 041__ $$aeng
000074916 100__ $$0(orcid)0000-0002-0595-5514$$aGarcía-Salinas, S.$$uUniversidad de Zaragoza
000074916 245__ $$aEvaluation of the antimicrobial activity and cytotoxicity of different components of natural origin present in essential oils
000074916 260__ $$c2018
000074916 5060_ $$aAccess copy available to the general public$$fUnrestricted
000074916 5203_ $$aEven though essential oils (EOs) have been used for therapeutic purposes, there is now a renewed interest in the antimicrobial properties of phytochemicals and EOs in particular. Their demonstrated low levels of induction of antimicrobial resistance make them interesting for bactericidal applications, though their complex composition makes it necessary to focus on the study of their main components to identify the most effective ones. Herein, the evaluation of the antimicrobial action of different molecules present in EOs against planktonic and biofilm-forming Gram-positive (Staphylococcus aureus) and Gram-negative (Escherichia coli) bacteria was assessed. The bactericidal mechanisms of the different molecules, as well as their cytocompatibility, were also studied. Carvacrol, cinnamaldehyde, and thymol exhibit the highest in vitro antimicrobial activities against E. coli and S. aureus, with membrane disruption the bactericidal mechanism identified. The addition of those compounds (=0.5 mg/mL) hampers S. aureus biofilm formation and partially eliminates preformed biofilms. The subcytotoxic values of the tested EO molecules (0.015–0.090 mg/mL) are lower than the minimum inhibitory and bactericidal concentrations obtained for bacteria (0.2–0.5 mg/mL) but are higher than that obtained for chlorhexidine (0.004 mg/mL), indicating the reduced cytotoxicity of EOs. Therefore, carvacrol, cinnamaldehyde, and thymol are molecules contained in EOs that could be used against E. coli– and S. aureus–mediated infections without a potential induction of bactericidal resistance and with lower cell toxicity than the conventional widely used chlorhexidine.
000074916 536__ $$9info:eu-repo/grantAgreement/ES/MINECO/CTQ2014-52384-R$$9info:eu-repo/grantAgreement/EC/FP7/614715/EU/A Photo-triggered On-demand Drug Delivery System for Chronic Pain/NANOHEDONISM
000074916 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000074916 590__ $$a3.06$$b2018
000074916 591__ $$aCHEMISTRY, MULTIDISCIPLINARY$$b67 / 172 = 0.39$$c2018$$dQ2$$eT2
000074916 591__ $$aBIOCHEMISTRY & MOLECULAR BIOLOGY$$b133 / 294 = 0.452$$c2018$$dQ2$$eT2
000074916 592__ $$a0.757$$b2018
000074916 593__ $$aAnalytical Chemistry$$c2018$$dQ1
000074916 593__ $$aChemistry (miscellaneous)$$c2018$$dQ1
000074916 593__ $$aDrug Discovery$$c2018$$dQ1
000074916 593__ $$aPhysical and Theoretical Chemistry$$c2018$$dQ1
000074916 593__ $$aMolecular Medicine$$c2018$$dQ1
000074916 593__ $$aOrganic Chemistry$$c2018$$dQ1
000074916 593__ $$aPharmaceutical Science$$c2018$$dQ1
000074916 593__ $$aMedicine (miscellaneous)$$c2018$$dQ1
000074916 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000074916 700__ $$aElizondo-Castillo, H.
000074916 700__ $$0(orcid)0000-0003-3165-0156$$aArruebo, M.$$uUniversidad de Zaragoza
000074916 700__ $$aMendoza, G.
000074916 700__ $$0(orcid)0000-0002-2966-9088$$aIrusta, S.$$uUniversidad de Zaragoza
000074916 7102_ $$15005$$2555$$aUniversidad de Zaragoza$$bDpto. Ing.Quím.Tecnol.Med.Amb.$$cÁrea Ingeniería Química
000074916 773__ $$g23 (2018), 1399 [18 pp]$$pMolecules$$tMolecules$$x1420-3049
000074916 8564_ $$s441707$$uhttps://zaguan.unizar.es/record/74916/files/texto_completo.pdf$$yVersión publicada
000074916 8564_ $$s103824$$uhttps://zaguan.unizar.es/record/74916/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000074916 909CO $$ooai:zaguan.unizar.es:74916$$particulos$$pdriver
000074916 951__ $$a2020-10-09-17:47:21
000074916 980__ $$aARTICLE