000074934 001__ 74934 000074934 005__ 20200117221607.0 000074934 0247_ $$2doi$$a10.3389/fchem.2018.00234 000074934 0248_ $$2sideral$$a107280 000074934 037__ $$aART-2018-107280 000074934 041__ $$aeng 000074934 100__ $$0(orcid)0000-0001-9475-6367$$aArtiga, A. 000074934 245__ $$aEffective in Vitro Photokilling by Cell-Adhesive Gold Nanorods 000074934 260__ $$c2018 000074934 5060_ $$aAccess copy available to the general public$$fUnrestricted 000074934 5203_ $$aUpon excitation of their localized surface plasmon resonance (LSPR) band, gold nanorods (AuNRs) show a characteristic light-to-heat transduction, a useful and versatile property for a range of biomedical applications such as photothermal therapy, drug delivery, optoacoustic imaging and biosensing, among others. Nanoparticle (NP)-mediated photothermal therapy (PTT) rests on the ability of nanomaterials to convert light energy into heat and can currently be considered as a promising method for selectively destroying tumor cells by (photo)-thermoablation. One inherent limitation to NP-mediated PTT is that the nanoparticles must arrive at the site of action to exert their function and this typically involves cellular internalization. Here we report the use of the Keggin-type polyoxometalate (POM) phosphotungstic acid (PTA) as an inorganic gelling agent for the encapsulation of plasmonic gold nanorods (AuNRs) inside a biocompatible and cell-adhesive chitosan hydrogel matrix. These functional sub-micrometric containers are non-cytotoxic and present the ability to adhere to the cytoplasmic membranes of cells avoiding any need for cellular internalization, rendering them as highly efficient thermoablating agents of eukaryotic cells in vitro. 000074934 536__ $$9info:eu-repo/grantAgreement/ES/CSIC/ComFuturo$$9info:eu-repo/grantAgreement/ES/DGA/FSE$$9info:eu-repo/grantAgreement/ES/MEC/FPU014-06249$$9info:eu-repo/grantAgreement/ES/MEC/FPU015-04482 000074934 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/ 000074934 590__ $$a3.782$$b2018 000074934 591__ $$aCHEMISTRY, MULTIDISCIPLINARY$$b53 / 172 = 0.308$$c2018$$dQ2$$eT1 000074934 592__ $$a1.018$$b2018 000074934 593__ $$aChemistry (miscellaneous)$$c2018$$dQ1 000074934 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion 000074934 700__ $$aGarcia-Embid, S. 000074934 700__ $$0(orcid)0000-0001-6995-4302$$aDe Matteis, L. 000074934 700__ $$0(orcid)0000-0003-4848-414X$$aMitchell, S.G.$$uUniversidad de Zaragoza 000074934 700__ $$0(orcid)0000-0003-1081-8482$$ade la Fuente, J.M.$$uUniversidad de Zaragoza 000074934 7102_ $$12013$$2765$$aUniversidad de Zaragoza$$bDpto. Química Orgánica$$cÁrea Química Orgánica 000074934 773__ $$g6 (2018), 234 [10 pp]$$pFront. chem.$$tFrontiers in chemistry$$x2296-2646 000074934 8564_ $$s621181$$uhttps://zaguan.unizar.es/record/74934/files/texto_completo.pdf$$yVersión publicada 000074934 8564_ $$s11379$$uhttps://zaguan.unizar.es/record/74934/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada 000074934 909CO $$ooai:zaguan.unizar.es:74934$$particulos$$pdriver 000074934 951__ $$a2020-01-17-21:46:48 000074934 980__ $$aARTICLE