ECG-based estimation of dispersion of APD restitution as a tool to stratify sotalol-induced arrhythmic risk
Mincholé, A. ; Bueno-Orovio, A. ; Laguna, P. (Universidad de Zaragoza) ; Pueyo, E. (Universidad de Zaragoza) ; Rodriguez, B.
Resumen: Background
Increased spatial dispersion of restitution properties has been associated to arrhythmic risk. An ECG-based index quantifying restitution dispersion, DRest, is evaluated in patients who experienced Torsades de Pointes (TdP) under sotalol challenge and compared with the response in healthy subjects.
Methods and Results
ECG recordings were analyzed for quantification of DRest and QTc, among others biomarkers. DRest provides improved discrimination following sotalol administration between TdP and healthy subjects ([min–max]: [0.18–0.22] vs [0.02–0.12]), compared to other biomarkers including QTc ([436–548 ms] vs [376–467 ms]). Results in healthy subjects are in agreement with simulations of sotalol effects on a human tissue electrophysiological model.
Conclusions
This case study supports the potential of DRest for improved arrhythmia risk stratification even with QTc values below 450 ms.
Idioma: Inglés
DOI: 10.1016/j.jelectrocard.2015.06.006
Año: 2015
Publicado en: JOURNAL OF ELECTROCARDIOLOGY 48, 5 (2015), 867-873
ISSN: 0022-0736
Factor impacto JCR: 1.29 (2015)
Categ. JCR: CARDIAC & CARDIOVASCULAR SYSTEMS rank: 93 / 124 = 0.75 (2015) - Q3 - T3
Factor impacto SCIMAGO: 0.559 - Cardiology and Cardiovascular Medicine (Q2)
Financiación: info:eu-repo/grantAgreement/ES/MINECO/TEC2013-42140-R
Financiación: info:eu-repo/grantAgreement/ES/MINECO/TIN2013-41998-R
Tipo y forma: Article (Published version)
Área (Departamento): Área Teoría Señal y Comunicac. (Dpto. Ingeniería Electrón.Com.)
You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use.
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Increased spatial dispersion of restitution properties has been associated to arrhythmic risk. An ECG-based index quantifying restitution dispersion, DRest, is evaluated in patients who experienced Torsades de Pointes (TdP) under sotalol challenge and compared with the response in healthy subjects.
Methods and Results
ECG recordings were analyzed for quantification of DRest and QTc, among others biomarkers. DRest provides improved discrimination following sotalol administration between TdP and healthy subjects ([min–max]: [0.18–0.22] vs [0.02–0.12]), compared to other biomarkers including QTc ([436–548 ms] vs [376–467 ms]). Results in healthy subjects are in agreement with simulations of sotalol effects on a human tissue electrophysiological model.
Conclusions
This case study supports the potential of DRest for improved arrhythmia risk stratification even with QTc values below 450 ms.
Idioma: Inglés
DOI: 10.1016/j.jelectrocard.2015.06.006
Año: 2015
Publicado en: JOURNAL OF ELECTROCARDIOLOGY 48, 5 (2015), 867-873
ISSN: 0022-0736
Factor impacto JCR: 1.29 (2015)
Categ. JCR: CARDIAC & CARDIOVASCULAR SYSTEMS rank: 93 / 124 = 0.75 (2015) - Q3 - T3
Factor impacto SCIMAGO: 0.559 - Cardiology and Cardiovascular Medicine (Q2)
Financiación: info:eu-repo/grantAgreement/ES/MINECO/TEC2013-42140-R
Financiación: info:eu-repo/grantAgreement/ES/MINECO/TIN2013-41998-R
Tipo y forma: Article (Published version)
Área (Departamento): Área Teoría Señal y Comunicac. (Dpto. Ingeniería Electrón.Com.)
You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use. Exportado de SIDERAL (2021-02-24-12:57:04)
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Record created 2018-12-12, last modified 2021-02-24