000075922 001__ 75922
000075922 005__ 20200117213749.0
000075922 0247_ $$2doi$$a10.1016/j.cej.2017.12.024
000075922 0248_ $$2sideral$$a105297
000075922 037__ $$aART-2018-105297
000075922 041__ $$aeng
000075922 100__ $$0(orcid)0000-0002-4678-7465$$aUson, L.
000075922 245__ $$aSingle phase microreactor for the continuous, high-temperature synthesis of <4¿nm superparamagnetic iron oxide nanoparticles
000075922 260__ $$c2018
000075922 5060_ $$aAccess copy available to the general public$$fUnrestricted
000075922 5203_ $$aThe reproducibility of key nanomaterial features is essential in nanomedicine applications where small changes of physical characteristics often lead to a very different behavior. In this regard, continuous microreactors are often advocated as a means to achieve highly precise synthesis of nanomaterials. However, when the synthesis must take place at high temperatures the use of these devices becomes restricted in terms of materials and practical problems (e.g. plugging of microchannels). Here we present the continuous synthesis of ultrasmall superparamagnetic iron oxide nanoparticles (SPIONs) through a polyol-based process at high temperatures (>200 °C). The microfluidic reactor designed allows SPION production at residence times under 1 min, was able to work continuously for 8 h without channel blockage and reached high production yields by coupling microreactors using stacked plates. The effect of operating conditions was optimized to produce homogeneous particles with a narrow particle size distribution. In summary, the microreactor developed in this work enables easy-to scale up, reproducible continuous production of SPIONs.
000075922 536__ $$9info:eu-repo/grantAgreement/EC/FP7/614715/EU/A Photo-triggered On-demand Drug Delivery System for Chronic Pain/NANOHEDONISM$$9info:eu-repo/grantAgreement/EC/FP7/321642/EU/Development of a microfluidic platform to produce nanomaterials and assessment on new nanotechnology applications/PLATFORM2NANO$$9info:eu-repo/grantAgreement/ES/DGA/FSE
000075922 540__ $$9info:eu-repo/semantics/openAccess$$aby-nc-nd$$uhttp://creativecommons.org/licenses/by-nc-nd/3.0/es/
000075922 590__ $$a8.355$$b2018
000075922 591__ $$aENGINEERING, ENVIRONMENTAL$$b2 / 52 = 0.038$$c2018$$dQ1$$eT1
000075922 591__ $$aENGINEERING, CHEMICAL$$b6 / 138 = 0.043$$c2018$$dQ1$$eT1
000075922 592__ $$a2.066$$b2018
000075922 593__ $$aChemical Engineering (miscellaneous)$$c2018$$dQ1
000075922 593__ $$aChemistry (miscellaneous)$$c2018$$dQ1
000075922 593__ $$aIndustrial and Manufacturing Engineering$$c2018$$dQ1
000075922 593__ $$aEnvironmental Chemistry$$c2018$$dQ1
000075922 593__ $$aEngineering (miscellaneous)$$c2018$$dQ4
000075922 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/acceptedVersion
000075922 700__ $$0(orcid)0000-0003-3165-0156$$aArruebo, M.$$uUniversidad de Zaragoza
000075922 700__ $$0(orcid)0000-0002-6873-5244$$aSebastian, V.$$uUniversidad de Zaragoza
000075922 700__ $$0(orcid)0000-0002-8701-9745$$aSantamaria, J.$$uUniversidad de Zaragoza
000075922 7102_ $$15005$$2555$$aUniversidad de Zaragoza$$bDpto. Ing.Quím.Tecnol.Med.Amb.$$cÁrea Ingeniería Química
000075922 773__ $$g340 (2018), 66-72$$pChem. eng. j.$$tChemical Engineering Journal$$x1385-8947
000075922 8564_ $$s550670$$uhttps://zaguan.unizar.es/record/75922/files/texto_completo.pdf$$yPostprint
000075922 8564_ $$s45556$$uhttps://zaguan.unizar.es/record/75922/files/texto_completo.jpg?subformat=icon$$xicon$$yPostprint
000075922 909CO $$ooai:zaguan.unizar.es:75922$$particulos$$pdriver
000075922 951__ $$a2020-01-17-21:31:38
000075922 980__ $$aARTICLE