000076018 001__ 76018
000076018 005__ 20190709135428.0
000076018 0247_ $$2doi$$a10.1016/j.ophtha.2017.01.005
000076018 0248_ $$2sideral$$a99026
000076018 037__ $$aART-2017-99026
000076018 041__ $$aeng
000076018 100__ $$0(orcid)0000-0001-6258-2489$$aGarcia-Martin, E.$$uUniversidad de Zaragoza
000076018 245__ $$aRetinal and Optic Nerve Degeneration in Patients with Multiple Sclerosis Followed up for 5 Years
000076018 260__ $$c2017
000076018 5060_ $$aAccess copy available to the general public$$fUnrestricted
000076018 5203_ $$aPurpose: To quantify retinal nerve fiber layer (RNFL) changes in patients with multiple sclerosis (MS) and healthy controls with a 5-year follow-up and to analyze correlations between disability progression and RNFL degeneration.
Design: Observational and longitudinal study.
Participants: One hundred patients with relapsing-remitting MS and 50 healthy controls.
Methods: All participants underwent a complete ophthalmic and electrophysiologic exploration and were re-evaluated annually for 5 years.
Main Outcome Measures: Visual acuity (Snellen chart), color vision (Ishihara pseudoisochromatic plates), visual field examination, optical coherence tomography (OCT), scanning laser polarimetry (SLP), and visual evoked potentials. Expanded Disability Status Scale (EDSS) scores, disease duration, treatments, prior optic neuritis episodes, and quality of life (QOL; based on the 54-item Multiple Sclerosis Quality of Life Scale score).
Results: Optical coherence tomography (OCT) revealed changes in all RNFL thicknesses in both groups. In the MS group, changes were detected in average thickness and in the mean deviation using the GDx-VCC nerve fiber analyzer (Laser Diagnostic Technologies, San Diego, CA) and in the P100 latency of visual evoked potentials; no changes were detected in visual acuity, color vision, or visual fields. Optical coherence tomography showed greater differences in the inferior and temporal RNFL thicknesses in both groups. In MS patients only, OCT revealed a moderate correlation between the increase in EDSS and temporal and superior RNFL thinning. Temporal RNFL thinning based on OCT results was correlated moderately with decreased QOL.
Conclusions: Multiple sclerosis patients exhibit a progressive axonal loss in the optic nerve fiber layer. Retinal nerve fiber layer thinning based on OCT results is a useful marker for assessing MS progression and correlates with increased disability and reduced QOL.
000076018 540__ $$9info:eu-repo/semantics/openAccess$$aby-nc-nd$$uhttp://creativecommons.org/licenses/by-nc-nd/3.0/es/
000076018 590__ $$a7.479$$b2017
000076018 591__ $$aOPHTHALMOLOGY$$b2 / 59 = 0.034$$c2017$$dQ1$$eT1
000076018 592__ $$a4.896$$b2017
000076018 593__ $$aOphthalmology$$c2017$$dQ1
000076018 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/acceptedVersion
000076018 700__ $$0(orcid)0000-0002-9788-2083$$aAra, J.R.
000076018 700__ $$aMartin, J.
000076018 700__ $$aAlmarcegui, C.
000076018 700__ $$aDolz, I.
000076018 700__ $$aVilades, E.
000076018 700__ $$aGil-Arribas, L.
000076018 700__ $$aFernandez, F.J.
000076018 700__ $$0(orcid)0000-0002-1402-3129$$aPolo, V.$$uUniversidad de Zaragoza
000076018 700__ $$0(orcid)0000-0002-6745-7668$$aLarrosa, J.M.$$uUniversidad de Zaragoza
000076018 700__ $$0(orcid)0000-0003-2389-8282$$aPablo, L.E.$$uUniversidad de Zaragoza
000076018 700__ $$aSatue, M.
000076018 7102_ $$11004$$2646$$aUniversidad de Zaragoza$$bDpto. Cirugía,Ginecol.Obstetr.$$cÁrea Oftalmología
000076018 773__ $$g124, 5 (2017), 688-696$$pOphthalmology$$tOPHTHALMOLOGY$$x0161-6420
000076018 8564_ $$s262547$$uhttps://zaguan.unizar.es/record/76018/files/texto_completo.pdf$$yPostprint
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000076018 951__ $$a2019-07-09-11:30:39
000076018 980__ $$aARTICLE