Arsenic exposure, diabetes-related genes and diabetes prevalence in a general population from Spain

Grau-Perez, M. ; Navas-Acien, A. ; Galan-Chilet, I. ; Briongos-Figuero, L.S. ; Morchon-Simon, D. ; Bermudez, J.D. ; Crainiceanu, C.M. ; de Marco, G. ; Rentero-Garrido, P. ; Garcia-Barrera, T. ; Gomez-Ariza, J.L. ; Casasnovas, J.A. (Universidad de Zaragoza) ; Martin-Escudero, J.C. ; Redon, J. ; Chaves, F.J. ; Tellez-Plaza, M.

Resumen: Inorganic arsenic exposure may be associated with diabetes, but the evidence at low-moderate levels is not sufficient. Polymorphisms in diabetes-related genes have been involved in diabetes risk. We evaluated the association of inorganic arsenic exposure on diabetes in the Hortega Study, a representative sample of a general population from Valladolid, Spain. Total urine arsenic was measured in 1451 adults. Urine arsenic speciation was available in 295 randomly selected participants. To account for the confounding introduced by non-toxic seafood arsenicals, we designed a multiple imputation model to predict the missing arsenobetaine levels. The prevalence of diabetes was 8.3%. The geometric mean of total arsenic was 66.0 µg/g. The adjusted odds ratios (95% confidence interval) for diabetes comparing the highest with the lowest tertile of total arsenic were 1.76 (1.01, 3.09) and 2.14 (1.47, 3.11) before and after arsenobetaine adjustment, respectively. Polymorphisms in several genes including IL8RA, TXN, NR3C2, COX5A and GCLC showed suggestive differential associations of urine total arsenic with diabetes. The findings support the role of arsenic on diabetes and the importance of controlling for seafood arsenicals in populations with high seafood intake. Suggestive arsenic-gene interactions require confirmation in larger studies.

Idioma: Inglés

DOI: 10.1016/j.envpol.2018.01.008

Año: 2018

Publicado en: Environmental Pollution 235 (2018), 948-955
ISSN: 0269-7491

Factor impacto JCR: 5.714 (2018)

Categ. JCR: ENVIRONMENTAL SCIENCES rank: 25 / 250 = 0.1 (2018) - Q1 - T1

Factor impacto SCIMAGO: 1.673 - Health, Toxicology and Mutagenesis (Q1) - Toxicology (Q1) - Pollution (Q1) - Medicine (miscellaneous) (Q1)

Financiación: info:eu-repo/grantAgreement/ES/ISCIII/CB06-03
Financiación: info:eu-repo/grantAgreement/ES/ISCIII/FIS/CP12-03080
Financiación: info:eu-repo/grantAgreement/ES/ISCIII/PI10-0082
Financiación: info:eu-repo/grantAgreement/ES/ISCIII/PI11-00726
Financiación: info:eu-repo/grantAgreement/ES/ISCIII/PI13-01848
Financiación: info:eu-repo/grantAgreement/ES/ISCIII/PI15-00071
Financiación: info:eu-repo/grantAgreement/ES/Spanish Ministry of Health/CIBERDEM CB07-08-018
Financiación: info:eu-repo/grantAgreement/ES/Spanish Ministry of Health/CIBERobn CB12-03-30016
Financiación: info:eu-repo/grantAgreement/ES/Spanish Ministry of Health/CIBER02-08-2009

Tipo y forma: Artículo (PostPrint)

Área (Departamento): Area Medicina (Dpto. Medicina, Psiqu. y Derm.)