Prevalence and progression of chronic kidney disease after a liver transplant: a prospective, real-life, observational, two-year multicenter study
Herrero, J.I. ; Cuervas-Mons, V. ; Gómez-Bravo, M.Á. ; Fabregat, J. ; Otero, A. ; Bilbao, I. ; Salcedo, M.M. ; González-Diéguez, M.L. ; Fernández, J.R. ; Serrano, M.T. (Universidad de Zaragoza) ; Jiménez, M. ; Rodrigo, J.M. ; Narváez, I. ; Sánchez, G.
Resumen: Introduction: chronic kidney disease is a frequent complication after liver transplantation. The use of calcineurin inhibitors is one of the causes of this complication. Current immunsuppression regimens that reduce the use of calcineurin inhibitors may be associated with an improved preservation of renal function. Objective: the study aimed to assess the evolution of renal function after liver transplantation in the current routine clinical practice.
Methods: an observational, prospective, multicenter study in adult liver transplant recipients was performed. Two hundred and thirty patients with a good renal function before transplantation were assessed six months post-transplantation (baseline) and every six months until month 30.
Results: at baseline, 32% of the patients had a reduction in the glomerular filtration rate below < 60 ml/min/1.73 m2. The mean glomerular filtration rate increased from 72.3 to 75.6 ml/min/1.73 m2 at baseline and month 30 respectively (p < 0.01). The mean serum creatinine levels (mg/dl) decreased from 1.13 to 1.09 (p < 0.01). The percentage of patients with stage 3 chronic kidney disease decreased from 31.7% to 26.4%, whereas the percentage of patients with stage 4 remained unchanged (0.4% at baseline and 0.5% at month 30). No patients progressed to end-stage kidney disease that required dialysis or renal transplantation.
Conclusion: in the routine clinical practice, a moderate deterioration of renal function is frequent after liver transplantation. However, advanced chronic kidney disease is infrequent in patients with a good pre-transplant renal function.
Idioma: Inglés
DOI: 10.17235/reed.2018.5431/2017
Año: 2018
Publicado en: REVISTA ESPANOLA DE ENFERMEDADES DIGESTIVAS 110, 9 (2018), 538-543
ISSN: 1130-0108
Factor impacto JCR: 1.858 (2018)
Categ. JCR: GASTROENTEROLOGY & HEPATOLOGY rank: 70 / 84 = 0.833 (2018) - Q4 - T3
Factor impacto SCIMAGO: 0.524 - Medicine (miscellaneous) (Q2) - Gastroenterology (Q2)
Tipo y forma: Article (Published version)
Área (Departamento): Area Medicina (Dpto. Medicina, Psiqu. y Derm.)
You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use. You may not use the material for commercial purposes. If you remix, transform, or build upon the material, you may not distribute the modified material.
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Methods: an observational, prospective, multicenter study in adult liver transplant recipients was performed. Two hundred and thirty patients with a good renal function before transplantation were assessed six months post-transplantation (baseline) and every six months until month 30.
Results: at baseline, 32% of the patients had a reduction in the glomerular filtration rate below < 60 ml/min/1.73 m2. The mean glomerular filtration rate increased from 72.3 to 75.6 ml/min/1.73 m2 at baseline and month 30 respectively (p < 0.01). The mean serum creatinine levels (mg/dl) decreased from 1.13 to 1.09 (p < 0.01). The percentage of patients with stage 3 chronic kidney disease decreased from 31.7% to 26.4%, whereas the percentage of patients with stage 4 remained unchanged (0.4% at baseline and 0.5% at month 30). No patients progressed to end-stage kidney disease that required dialysis or renal transplantation.
Conclusion: in the routine clinical practice, a moderate deterioration of renal function is frequent after liver transplantation. However, advanced chronic kidney disease is infrequent in patients with a good pre-transplant renal function.
Idioma: Inglés
DOI: 10.17235/reed.2018.5431/2017
Año: 2018
Publicado en: REVISTA ESPANOLA DE ENFERMEDADES DIGESTIVAS 110, 9 (2018), 538-543
ISSN: 1130-0108
Factor impacto JCR: 1.858 (2018)
Categ. JCR: GASTROENTEROLOGY & HEPATOLOGY rank: 70 / 84 = 0.833 (2018) - Q4 - T3
Factor impacto SCIMAGO: 0.524 - Medicine (miscellaneous) (Q2) - Gastroenterology (Q2)
Tipo y forma: Article (Published version)
Área (Departamento): Area Medicina (Dpto. Medicina, Psiqu. y Derm.)
You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use. You may not use the material for commercial purposes. If you remix, transform, or build upon the material, you may not distribute the modified material. Exportado de SIDERAL (2024-01-11-10:59:11)
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Record created 2019-01-25, last modified 2024-01-11