000077118 001__ 77118 000077118 005__ 20210520140805.0 000077118 037__ $$aTESIS-2019-056 000077118 041__ $$aeng 000077118 1001_ $$aAlbisa Novo, Airama 000077118 24500 $$aAdvances in particle engineering for pharmaceutical applications 000077118 260__ $$aZaragoza$$bUniversidad de Zaragoza, Prensas de la Universidad$$c2018 000077118 300__ $$a211 000077118 4900_ $$aTesis de la Universidad de Zaragoza$$v2019-36$$x2254-7606 000077118 500__ $$aPresentado: 23 11 2018 000077118 502__ $$aTesis-Univ. Zaragoza, Ingeniería Química y Tecnologías del Medio Ambiente, 2018$$bZaragoza, Universidad de Zaragoza$$c2018 000077118 506__ $$aall-rights-reserved 000077118 520__ $$aBiodegradable nano/microparticles have extensive value as vehicles for drug delivery and form the basis of several therapies approved by the US Food and Drug Administration. One of the hurdles to overcome in the use of those materials as drug delivery vectors is their availability at industrial scale. Innovation in process technology is required to translate laboratory production into mass production while preserving their desired characteristics. <br />The transition between proof of concept and application in drug delivery system is not a simple task being the main reason that only a few drug delivery system products arrive to the market. Different challenges need to be overcome to meet the specific requirements of reproducibility, energy consumption, control of toxicity, environmental impact and productivity required for industrial application. Moreover there is a need for methodologies as basis for the scaling up of processes.<br />The main goal of this work is to develop a methodology for the production of a variety of particles (nano and microparticles). The synthesis mechanisms will be based on emulsification and nanoprecipitation by using two promising production approaches, membrane and millifluidic devices.<br />The specific goals to achieve are: <br />- Development of nano and micro emulsification techniques to produce nano/micro particles based on membrane emulsification and millifluidic devices.<br />- Control and tune the size distribution of particles according to the therapeutic target application (including administration route, biodistribution, target organ).<br />- Assessment of the proper drug encapsulation/loading to the required sustained release achieve a good control on the rate of drug release as well as on the burst release to improve the sustained drug delivery.<br />- Study of drug release pharmaco-kinetics in physiological conditions.<br />- Study the sustainability of the particle production process. <br /> 000077118 520__ $$a<br /> 000077118 521__ $$97103$$aPrograma de Doctorado en Ingeniería Química y del Medio ambiente 000077118 6531_ $$afenomenos de membrana 000077118 6531_ $$aemulsiones 000077118 6531_ $$aprecipitacion 000077118 6531_ $$aprocesos de mezclado 000077118 700__ $$aSebastián Cabeza, Víctor$$edir. 000077118 700__ $$aMeireles-Masbernat, Martine$$edir. 000077118 700__ $$aPiacentini, Emma$$edir. 000077118 7102_ $$aUniversidad de Zaragoza$$bIngeniería Química y Tecnologías del Medio Ambiente 000077118 830__ $$9515 000077118 8560_ $$ftdr@unizar.es 000077118 8564_ $$uhttps://zaguan.unizar.es/record/77118/files/TESIS-2019-056.pdf$$zTexto completo (eng) 000077118 909CO $$ooai:zaguan.unizar.es:77118$$pdriver 000077118 909co $$ptesis 000077118 9102_ $$a$$bIngeniería Química y Tecnologías del Medio Ambiente 000077118 980__ $$aTESIS