CD30-positive primary cutaneous lymphoproliferative disorders: molecular alterations and targeted therapies

Prieto-Torres, L. ; Rodriguez-Pinilla, S.M. ; Onaindia, A. ; Ara, M. (Universidad de Zaragoza) ; Requena, L. ; Piris, M.Á.

Resumen: Primary cutaneous CD30-positive T-cell lymphoproliferative disorders are the second most common subgroup of cutaneous T-cell lymphomas. They include two clinically different entities with some overlapping features and borderline cases: lymphomatoid papulosis and primary cutaneous anaplastic large cell lymphoma. Molecular studies of primary cutaneous anaplastic large cell lymphoma reveal an increasing level of heterogeneity that is associated with histological and immunophenotypic features of the cases and their response to specific therapies. Here, we review the most significant genetic, epigenetic and molecular alterations described to date in primary cutaneous CD30-positive T-cell lymphoproliferative disorders, and their potential as therapeutic targets.

Idioma: Inglés

DOI: 10.3324/haematol.2018.197152

Año: 2019

Publicado en: Haematologica 104, 2 (2019), 226-235
ISSN: 0390-6078

Factor impacto JCR: 7.116 (2019)

Categ. JCR: HEMATOLOGY rank: 7 / 76 = 0.092 (2019) - Q1 - T1

Factor impacto SCIMAGO: 2.931 - Hematology (Q1)

Financiación: info:eu-repo/grantAgreement/ES/MINECO-RTICC-ISCIII-CIBERONC/PIE15-0081
Financiación: info:eu-repo/grantAgreement/ES/MINECO-RTICC-ISCIII-CIBERONC/PI16-01294
Financiación: info:eu-repo/grantAgreement/ES/MINECO-RTICC-ISCIII-CIBERONC/PI17-2172
Financiación: info:eu-repo/grantAgreement/ES/MINECO-RTICC-ISCIII-CIBERONC/RD06-0020-0107-RD012-0036-0060
Financiación: info:eu-repo/grantAgreement/ES/MINECO-RTICC-ISCIII-CIBERONC/SAF2013-47416-R

Tipo y forma: Revisión (Versión definitiva)

Área (Departamento): Área Dermatología (Dpto. Medicina, Psiqu. y Derm.)