000078767 001__ 78767
000078767 005__ 20201009175923.0
000078767 0247_ $$2doi$$a10.1039/c7nr06020c
000078767 0248_ $$2sideral$$a104184
000078767 037__ $$aART-2018-104184
000078767 041__ $$aeng
000078767 100__ $$aMarín-Barba, M.
000078767 245__ $$aUnravelling the mechanisms that determine the uptake and metabolism of magnetic single and multicore nanoparticles in a: Xenopus laevis model
000078767 260__ $$c2018
000078767 5060_ $$aAccess copy available to the general public$$fUnrestricted
000078767 5203_ $$aMulticore superparamagnetic nanoparticles have been proposed as ideal tools for some biomedical applications because of their high magnetic moment per particle, high specific surface area and long term colloidal stability. Through controlled aggregation and packing of magnetic cores it is possible to obtain not only single-core but also multicore and hollow spheres with internal voids. In this work, we compare toxicological properties of single and multicore nanoparticles. Both types of particles showed moderate in vitro toxicity (MTT assay) tested in Hep G2 (human hepatocellular carcinoma) and Caco-2 (human colorectal adenocarcinoma) cells. The influence of surface chemistry in their biological behavior was also studied after functionalization with O, O'-bis(2-aminoethyl) PEG (2000 Da). For the first time, these nanoparticles were evaluated in a Xenopus laevis model studying their whole organism toxicity and their impact upon iron metabolism. The degree of activation of the metabolic pathway depends on the size and surface charge of the nanoparticles which determine their uptake. The results also highlight the potential of Xenopus laevis model bridging the gap between in vitro cell-based assays and rodent models for toxicity assessment to develop effective nanoparticles for biomedical applications.
000078767 536__ $$9info:eu-repo/grantAgreement/ES/MINECO/MAT2014-52069-R$$9This project has received funding from the European Union’s Horizon 2020 research and innovation program under grant agreement No H2020 705089-MIR-CHROM-C$$9info:eu-repo/grantAgreement/EC/H2020/705089/EU/Investigating the microRNA-chromatin remodelling circuitry in cardiac development/MIR-CHROM-C$$9info:eu-repo/grantAgreement/EC/FP7/612338/EU/DNA-TRAP Delivery of Nucleic Acid-Based Therapeutics for the TReatment of Antibiotic-Resistant Pathogens/DNA-TRAP$$9info:eu-repo/grantAgreement/EC/FP7/607142/EU/European Initial Training Network on Developmental and Computational Biology/DEVCOM$$9info:eu-repo/grantAgreement/EC/FP7/604448/EU/Nanometrology Standardization Methods for Magnetic Nanoparticles/NANOMAG$$9info:eu-repo/grantAgreement/ES/MINECO/RYC-2014-15512
000078767 540__ $$9info:eu-repo/semantics/openAccess$$aAll rights reserved$$uhttp://www.europeana.eu/rights/rr-f/
000078767 590__ $$a6.97$$b2018
000078767 591__ $$aMATERIALS SCIENCE, MULTIDISCIPLINARY$$b41 / 293 = 0.14$$c2018$$dQ1$$eT1
000078767 591__ $$aNANOSCIENCE & NANOTECHNOLOGY$$b20 / 94 = 0.213$$c2018$$dQ1$$eT1
000078767 591__ $$aCHEMISTRY, MULTIDISCIPLINARY$$b26 / 172 = 0.151$$c2018$$dQ1$$eT1
000078767 591__ $$aPHYSICS, APPLIED$$b18 / 148 = 0.122$$c2018$$dQ1$$eT1
000078767 592__ $$a2.396$$b2018
000078767 593__ $$aNanoscience and Nanotechnology$$c2018$$dQ1
000078767 593__ $$aMaterials Science (miscellaneous)$$c2018$$dQ1
000078767 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/acceptedVersion
000078767 700__ $$aGavilán, H.
000078767 700__ $$0(orcid)0000-0003-2366-3598$$aGutiérrez, L.$$uUniversidad de Zaragoza
000078767 700__ $$aLozano-Velasco, E.
000078767 700__ $$aRodríguez-Ramiro, I.
000078767 700__ $$aWheeler, G.N.
000078767 700__ $$aMorris, C.J.
000078767 700__ $$aMorales, M.P.
000078767 700__ $$aRuiz, A.
000078767 7102_ $$12009$$2750$$aUniversidad de Zaragoza$$bDpto. Química Analítica$$cÁrea Química Analítica
000078767 773__ $$g10, 2 (2018), 690-704$$pNanoscale$$tNanoscale$$x2040-3364
000078767 8564_ $$s700594$$uhttps://zaguan.unizar.es/record/78767/files/texto_completo.pdf$$yPostprint
000078767 8564_ $$s47396$$uhttps://zaguan.unizar.es/record/78767/files/texto_completo.jpg?subformat=icon$$xicon$$yPostprint
000078767 909CO $$ooai:zaguan.unizar.es:78767$$particulos$$pdriver
000078767 951__ $$a2020-10-09-17:47:08
000078767 980__ $$aARTICLE