Cytotoxic gold(I) complexes with amidophosphine ligands containing thiophene moieties

Goitia, H. ; Villacampa, M.D. (Universidad de Zaragoza) ; Laguna, A. (Universidad de Zaragoza) ; Gimeno, M.C. (Universidad de Zaragoza)

Resumen: A new phosphine ligand bearing a thiophene moiety, C 4 H 3 SNHCOCH 2 CH 2 PPh 2 (L), has been prepared by reaction of the aminophosphine Ph 2 PCH 2 CH 2 NH 2 with thiophenecarbonylchloride in the presence of triethylamine. The coordination behavior towards gold(I), gold(III) and silver(I) species has been studied and several metal compounds of different stoichiometry have been achieved, such as [AuL 2 ]OTf, [AuXL] (X = Cl, C 6 F 5 ), [Au(C 6 F 5 ) 3 L], [AgL 2 ]OTf or [Ag(OTf)L]. Additionally, the reactivity of the chloride gold(I) species with biologically relevant thiolates was explored, thus obtaining the neutral thiolate compounds [AuL(SR)] (SR = 2-thiocitosine, 2-thiolpyridine, 2-thiouracil, 2-thionicotinic acid, 2, 3, 4, 6-tetra-6-acetyl-1-thiol-ß-D-glucopyranosato or thiopurine). The antitumor activity of the compounds was measured by the MTT method in several cancer cells and the complexes exhibit excellent cytotoxic activity.

Idioma: Inglés

DOI: 10.3390/inorganics7020013

Año: 2019

Publicado en: Inorganics 7, 2 (2019), 13 [13 pp]
ISSN: 2304-6740

Factor impacto SCIMAGO: 0.482 - Inorganic Chemistry (Q2)

Financiación: info:eu-repo/grantAgreement/ES/DGA-FSE/E07-17R
Financiación: info:eu-repo/grantAgreement/ES/MINECO/CTQ2016-75816-C2-1-P

Tipo y forma: Article (Published version)

Área (Departamento): Área Química Inorgánica (Dpto. Química Inorgánica)