000084378 001__ 84378
000084378 005__ 20201019094020.0
000084378 0247_ $$2doi$$a10.3390/nu11092253
000084378 0248_ $$2sideral$$a113999
000084378 037__ $$aART-2019-113999
000084378 041__ $$aeng
000084378 100__ $$aDel Olmo, Nuria
000084378 245__ $$aDifferential Impact of Ad Libitum or Intermittent High-Fat Diets on Bingeing Ethanol-Mediated Behaviors
000084378 260__ $$c2019
000084378 5060_ $$aAccess copy available to the general public$$fUnrestricted
000084378 5203_ $$aBACKGROUND: Dietary factors have significant effects on the brain, modulating mood, anxiety, motivation and cognition. To date, no attention has been paid to the consequences that the combination of ethanol (EtOH) and a high-fat diet (HFD) have on learning and mood disorders during adolescence. The aim of the present work was to evaluate the biochemical and behavioral consequences of ethanol binge drinking and an HFD consumption in adolescent mice. METHODS: Animals received either a standard diet or an HFD (ad libitum vs. binge pattern) in combination with ethanol binge drinking and were evaluated in anxiety and memory. The metabolic profile and gene expression of leptin receptors and clock genes were also evaluated. RESULTS: Excessive white adipose tissue and an increase in plasma insulin and leptin levels were mainly observed in ad libitum HFD + EtOH mice. An upregulation of the Lepr gene expression in the prefrontal cortex and the hippocampus was also observed in ad libitum HFD groups. EtOH-induced impairment on spatial memory retrieval was absent in mice exposed to an HFD, although the aversive memory deficits persisted. Mice bingeing on an HFD only showed an anxiolytic profile, without other alterations. We also observed a mismatch between Clock and Bmal1 expression in ad libitum HFD animals, which were mostly independent of EtOH bingeing. CONCLUSIONS: Our results confirm the bidirectional influence that occurs between the composition and intake pattern of a HFD and ethanol consumption during adolescence, even when the metabolic, behavioral and chronobiological effects of this interaction are dissociated.
000084378 536__ $$9info:eu-repo/grantAgreement/ES/ISCIII/RD12-0028-0005$$9info:eu-repo/grantAgreement/ES/ISCIII/RD16-0017-0007$$9info:eu-repo/grantAgreement/ES/MINECO/BFU2016-68556-R
000084378 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000084378 590__ $$a4.546$$b2019
000084378 591__ $$aNUTRITION & DIETETICS$$b17 / 89 = 0.191$$c2019$$dQ1$$eT1
000084378 592__ $$a1.329$$b2019
000084378 593__ $$aNutrition and Dietetics$$c2019$$dQ1
000084378 593__ $$aFood Science$$c2019$$dQ1
000084378 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000084378 700__ $$0(orcid)0000-0001-5990-1266$$aBlanco-Gandía, M.Carmen$$uUniversidad de Zaragoza
000084378 700__ $$aMateos-García, Ana
000084378 700__ $$aDel Rio, Danila
000084378 700__ $$aMiñarro, José
000084378 700__ $$aRuiz-Gayo, Mariano
000084378 700__ $$aRodríguez-Arias, Marta
000084378 7102_ $$14009$$2735$$aUniversidad de Zaragoza$$bDpto. Psicología y Sociología$$cÁrea Psicolog.Evolut.Educac
000084378 773__ $$g11, 9 (2019), 2253 [18 pp.]$$pNUTRIENTS$$tNutrients$$x2072-6643
000084378 8564_ $$s1119480$$uhttps://zaguan.unizar.es/record/84378/files/texto_completo.pdf$$yVersión publicada
000084378 8564_ $$s103564$$uhttps://zaguan.unizar.es/record/84378/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000084378 909CO $$ooai:zaguan.unizar.es:84378$$particulos$$pdriver
000084378 951__ $$a2020-10-19-09:35:51
000084378 980__ $$aARTICLE