@article{GuzmánCarreras:8590,
author = "Guzmán Carreras, Beira and Abad Alegría, Francisco",
title = "{Mecanismo de acción del levetiracetam: una aproximación
a partir de sus efectos en el EEG}",
year = "2012",
note = "Objectives: to identify the frequency of appearance of
fast rhythms in the EEG in patients using levetiracetam
(LEV), observe potential drug interaction of LEV with
benzodiazepines and barbiturates, which provide fast
rhythms on EEG and reach an approximation of the mechanism
of action LEV. Material and methods: a longitudinal cohort
study in the time between February 2011 and May 2012,
patients attending the laboratory of Clinical
Neurophysiology. We collected a total of 141 patients,
mostly from the Neurology and Pediatrics, EEGs were
performed with the inclusion criteria that they used the
drug LEV as usual or for 24 hours before the time of
examination. Manually analyzed EEGs each area by the
physicians taking into account parameters of interest to
assess the earlier rapid pace. Results: mean age was 53
years, of whom 70 patients (49.6%) had rapid rates. Only 16
patients used benzodiazepines (BZPs), most females.
Considering only patients who presented as finding a
frequency above 14 Hz greater than could say that prevails
to a greater extent the rise in Hz with the use of BZP with
the study drug and no relation to the type of epilepsy and
the amount of fast rhythm in patients presented.
Conclusion: we observed that like the BZPs and
barbiturates, the LEV provides fast rhythms are not as
quick in the BZPs frequencies and barbiturates, as in our
previous study, the maximum frequency was 26Hz and was in a
patient LEV concurrently with BZP use, so that high
frequency could be due to BZP and not the LEV. We conclude
that according to the performance of the LEV that by some
mechanism as yet unknown experimentally, the LEV could
stimulate areas in the reticular formation and this in turn
provides stimulus to thalamus and cortex, resulting in high
frequency EEG rhythm and low voltage, similar to those
provided in wakefulness.",
}