| TAZ-TFM-2012-608 |
Mecanismo de acción del levetiracetam: una aproximación a partir de sus efectos en el EEG
Guzmán Carreras, Beira
Abad Alegría, Francisco (dir.)
Abad Alegría, Francisco (ponente)
Universidad de Zaragoza,
MED,
2012
Medicina, Psiquiatría y Dermatología department, Medicina area
Máster Universitario en Iniciación a la Investigación en Medicina
Free keyword(s): eeg ; sara ; sistema activador reticular ascendente ; levetiracetam ; benzodiacepinas
Tipo de Trabajo Académico: Trabajo Fin de Master
Notas: Objectives: to identify the frequency of appearance of fast rhythms in the EEG in patients using levetiracetam (LEV), observe potential drug interaction of LEV with benzodiazepines and barbiturates, which provide fast rhythms on EEG and reach an approximation of the mechanism of action LEV. Material and methods: a longitudinal cohort study in the time between February 2011 and May 2012, patients attending the laboratory of Clinical Neurophysiology. We collected a total of 141 patients, mostly from the Neurology and Pediatrics, EEGs were performed with the inclusion criteria that they used the drug LEV as usual or for 24 hours before the time of examination. Manually analyzed EEGs each area by the physicians taking into account parameters of interest to assess the earlier rapid pace. Results: mean age was 53 years, of whom 70 patients (49.6%) had rapid rates. Only 16 patients used benzodiazepines (BZPs), most females. Considering only patients who presented as finding a frequency above 14 Hz greater than could say that prevails to a greater extent the rise in Hz with the use of BZP with the study drug and no relation to the type of epilepsy and the amount of fast rhythm in patients presented. Conclusion: we observed that like the BZPs and barbiturates, the LEV provides fast rhythms are not as quick in the BZPs frequencies and barbiturates, as in our previous study, the maximum frequency was 26Hz and was in a patient LEV concurrently with BZP use, so that high frequency could be due to BZP and not the LEV. We conclude that according to the performance of the LEV that by some mechanism as yet unknown experimentally, the LEV could stimulate areas in the reticular formation and this in turn provides stimulus to thalamus and cortex, resulting in high frequency EEG rhythm and low voltage, similar to those provided in wakefulness.
Permalink:
El registro pertenece a las siguientes colecciones:
trabajos-academicos-universidad-zaragoza > centro > facultad-de-medicina
trabajos-academicos-universidad-zaragoza > trabajos-fin-master