000087570 001__ 87570
000087570 005__ 20210902121611.0
000087570 0247_ $$2doi$$a10.3390/antiox9010017
000087570 0248_ $$2sideral$$a115749
000087570 037__ $$aART-2020-115749
000087570 041__ $$aeng
000087570 100__ $$aMármol, Inés
000087570 245__ $$aA combination of Rosa canina extracts and gold complex favors apoptosis of caco-2 cells by increasing oxidative stress and mitochondrial dysfunction
000087570 260__ $$c2020
000087570 5060_ $$aAccess copy available to the general public$$fUnrestricted
000087570 5203_ $$aGiven the alarming increase in colorectal cancer (CRC) worldwide, novel therapies are urgently needed. Plant-derived extracts have gained considerable interest in the last years due to their strong anticancer effect mediated by their unique bioactive compounds. Specifically, rosehips from Rosa canina have been successfully tested against several cancer models, including colon cancer. Moreover, gold derivatives are a promising alternative to the current platinum-based drugs commonly used in CRC chemotherapy due to their lack of affinity for DNA. Herein we have investigated the antitumor potential of a drug combination made of acidic polyphenols extracted from R. canina and the gold complex (Au(C=C-2-NC5H4) (PTA)) in Caco-2 cell line as a model of CRC. The combination triggered strong apoptosis mediated by a blockage of the autophagic flux, which might be a consequence of a reactive oxygen species (ROS) increase and mitochondrial dysfunctionality. Our results suggest that the clinical application of plant polyphenols might enhance the anticancer effect of metallodrugs and reduce drug exposure time and therefore its side effects.
000087570 536__ $$9info:eu-repo/grantAgreement/ES/DGA/B16-R17$$9info:eu-repo/grantAgreement/ES/DGA/E07-17R$$9info:eu-repo/grantAgreement/EUR/INTERREG-POCTEFA/EFA 220-11-ELENA$$9info:eu-repo/grantAgreement/ES/ISCIII/CB06-03-1012$$9info:eu-repo/grantAgreement/ES/MINECO/CTQ2016-75816-C2-1-P$$9info:eu-repo/grantAgreement/ES/MINECO/SAF2016-75441-R$$9info:eu-repo/grantAgreement/EUR/SUDOE/INTERREG/Redvalue-SOE1-PI-E0123
000087570 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000087570 590__ $$a6.312$$b2020
000087570 591__ $$aBIOCHEMISTRY & MOLECULAR BIOLOGY$$b60 / 297 = 0.202$$c2020$$dQ1$$eT1
000087570 591__ $$aFOOD SCIENCE & TECHNOLOGY$$b11 / 144 = 0.076$$c2020$$dQ1$$eT1
000087570 591__ $$aCHEMISTRY, MEDICINAL$$b6 / 63 = 0.095$$c2020$$dQ1$$eT1
000087570 592__ $$a1.066$$b2020
000087570 593__ $$aBiochemistry$$c2020$$dQ2
000087570 593__ $$aCell Biology$$c2020$$dQ2
000087570 593__ $$aPhysiology$$c2020$$dQ2
000087570 593__ $$aMolecular Biology$$c2020$$dQ2
000087570 593__ $$aClinical Biochemistry$$c2020$$dQ2
000087570 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000087570 700__ $$aJiménez-Moreno, Nerea
000087570 700__ $$aAncín-Azpilicueta, Carmen
000087570 700__ $$0(orcid)0000-0002-8251-8457$$aOsada, Jesús$$uUniversidad de Zaragoza
000087570 700__ $$0(orcid)0000-0003-2457-3674$$aCerrada, Elena$$uUniversidad de Zaragoza
000087570 700__ $$0(orcid)0000-0002-3595-7668$$aRodríguez-Yoldi, María Jesús$$uUniversidad de Zaragoza
000087570 7102_ $$12010$$2760$$aUniversidad de Zaragoza$$bDpto. Química Inorgánica$$cÁrea Química Inorgánica
000087570 7102_ $$11005$$2410$$aUniversidad de Zaragoza$$bDpto. Farmacología y Fisiolog.$$cÁrea Fisiología
000087570 7102_ $$11002$$2060$$aUniversidad de Zaragoza$$bDpto. Bioq.Biolog.Mol. Celular$$cÁrea Bioquímica y Biolog.Mole.
000087570 773__ $$g9, 1 (2020), 17 [12 pp.]$$pAntioxidants$$tAntioxidants$$x2076-3921
000087570 8564_ $$s815211$$uhttps://zaguan.unizar.es/record/87570/files/texto_completo.pdf$$yVersión publicada
000087570 8564_ $$s103999$$uhttps://zaguan.unizar.es/record/87570/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000087570 909CO $$ooai:zaguan.unizar.es:87570$$particulos$$pdriver
000087570 951__ $$a2021-09-02-08:41:17
000087570 980__ $$aARTICLE