Influence of gender on prognosis of acute coronary syndromes
Cabrerizo-García, José Luis ; Pérez-Calvo, Juan Ignacio (Universidad de Zaragoza) ; Zalba-Etayo, Begoña (Universidad de Zaragoza)
Resumen: Introduction Ischemic heart disease presents different features in men and women. We analyzed the relation between gender and prognosis in patients who had suffered a high-risk acute coronary syndrome (ACS).
Methods This was a prospective analytical cohort study performed at Lozano Blesa University Hospital, Zaragoza, Spain, of 559 patients diagnosed with high-risk ACS with and without ST-segment elevation according to the American College of Cardiology/American Heart Association guidelines. The sample was divided into two groups by gender and differences in epidemiologic, laboratory, electrocardiographic and echocardiographic variables and treatment were recorded. A Cox's proportional hazard model was applied and 6-month mortality was analyzed as the main variable.
Results The median age was 65.2±12.7 years, and 21.8% were women. Baseline characteristics in women were more unfavorable, with higher GRACE scores, older age, higher prevalence of hypertension, diabetes and heart failure, lower ejection fraction and more renal dysfunction at admission. Women suffered more adverse cardiovascular events (27.9% vs. 15.8%, p=0.002). Sixty-four patients died, 18.9% of the women vs. 9.4% of the men (p=0.004). After multivariate analysis, female gender did not present an independent relation with mortality. Hemoglobin level, renal function, ejection fraction and Killip class >1 presented significant differences.
Conclusions Acute syndrome coronary in women has a worse prognosis than in men. Their adverse course is due to their baseline characteristics and not to their gender.
Idioma: Inglés
DOI: 10.1016/j.repc.2014.07.008
Año: 2015
Publicado en: Revista portuguesa de cardiologia 34, 1 (2015), 43-50
ISSN: 0870-2551
Factor impacto JCR: 0.873 (2015)
Categ. JCR: CARDIAC & CARDIOVASCULAR SYSTEMS rank: 109 / 124 = 0.879 (2015) - Q4 - T3
Factor impacto SCIMAGO: 0.291 - Cardiology and Cardiovascular Medicine (Q3)
Tipo y forma: Artículo (Versión definitiva)
Área (Departamento): Area Medicina (Dpto. Medicina, Psiqu. y Derm.)
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Methods This was a prospective analytical cohort study performed at Lozano Blesa University Hospital, Zaragoza, Spain, of 559 patients diagnosed with high-risk ACS with and without ST-segment elevation according to the American College of Cardiology/American Heart Association guidelines. The sample was divided into two groups by gender and differences in epidemiologic, laboratory, electrocardiographic and echocardiographic variables and treatment were recorded. A Cox's proportional hazard model was applied and 6-month mortality was analyzed as the main variable.
Results The median age was 65.2±12.7 years, and 21.8% were women. Baseline characteristics in women were more unfavorable, with higher GRACE scores, older age, higher prevalence of hypertension, diabetes and heart failure, lower ejection fraction and more renal dysfunction at admission. Women suffered more adverse cardiovascular events (27.9% vs. 15.8%, p=0.002). Sixty-four patients died, 18.9% of the women vs. 9.4% of the men (p=0.004). After multivariate analysis, female gender did not present an independent relation with mortality. Hemoglobin level, renal function, ejection fraction and Killip class >1 presented significant differences.
Conclusions Acute syndrome coronary in women has a worse prognosis than in men. Their adverse course is due to their baseline characteristics and not to their gender.
Idioma: Inglés
DOI: 10.1016/j.repc.2014.07.008
Año: 2015
Publicado en: Revista portuguesa de cardiologia 34, 1 (2015), 43-50
ISSN: 0870-2551
Factor impacto JCR: 0.873 (2015)
Categ. JCR: CARDIAC & CARDIOVASCULAR SYSTEMS rank: 109 / 124 = 0.879 (2015) - Q4 - T3
Factor impacto SCIMAGO: 0.291 - Cardiology and Cardiovascular Medicine (Q3)
Tipo y forma: Artículo (Versión definitiva)
Área (Departamento): Area Medicina (Dpto. Medicina, Psiqu. y Derm.)
Debe reconocer adecuadamente la autoría, proporcionar un enlace a la licencia e indicar si se han realizado cambios. Puede hacerlo de cualquier manera razonable, pero no de una manera que sugiera que tiene el apoyo del licenciador o lo recibe por el uso que hace. No puede utilizar el material para una finalidad comercial. Si remezcla, transforma o crea a partir del material, no puede difundir el material modificado.Exportado de SIDERAL (2023-10-27-12:53:12)
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Registro creado el 2020-05-22, última modificación el 2023-10-27