000089274 001__ 89274
000089274 005__ 20210902121631.0
000089274 0247_ $$2doi$$a10.3390/jcm9020398
000089274 0248_ $$2sideral$$a117538
000089274 037__ $$aART-2020-117538
000089274 041__ $$aeng
000089274 100__ $$aMoreno, Ricardo
000089274 245__ $$aInfluence of Serum Vitamin D Level in the Response of Actinic Keratosis to Photodynamic Therapy with Methylaminolevulinate
000089274 260__ $$c2020
000089274 5060_ $$aAccess copy available to the general public$$fUnrestricted
000089274 5203_ $$aIn mouse models of squamous cell carcinoma, pre-treatment with calcitriol prior to photodynamic therapy with aminolevulinic acid (ALA) enhances tumor cell death. We have evaluated the association between vitamin D status and the response of actinic keratoses to photodynamic therapy with methylaminolevulinate. Twenty-five patients with actinic keratoses on the head received one session of photodynamic therapy with methylaminolevulinate. Biopsies were taken at baseline and six weeks after treatment. Immuno-histochemical staining was performed for VDR, P53, Ki67 and beta-catenin. Basal serum 25(OH)D levels were determined. Cases with a positive histological response to treatment had significantly higher serum 25(OH)D levels (26.96 (SD 7.49) ngr/mL) than those without response (18.60 (SE 7.49) ngr/mL) (p = 0.05). Patients with a complete clinical response displayed lower basal VDR expression (35.71% (SD 19.88)) than partial responders (62.78% (SD 16.735)), (p = 0.002). Our results support a relationship between vitamin D status and the response of actinic keratoses to photodynamic therapy with methylaminolevulinate.
000089274 536__ $$9info:eu-repo/grantAgreement/ES/ISCIII/PI18-00858
000089274 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000089274 590__ $$a4.241$$b2020
000089274 591__ $$aMEDICINE, GENERAL & INTERNAL$$b39 / 169 = 0.231$$c2020$$dQ1$$eT1
000089274 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000089274 700__ $$aNajera, Laura
000089274 700__ $$aMascaraque, Marta
000089274 700__ $$aJuarranz, Ángeles
000089274 700__ $$aGonzalez, Salvador
000089274 700__ $$0(orcid)0000-0001-8034-3617$$aGilaberte, Yolanda$$uUniversidad de Zaragoza
000089274 7102_ $$11007$$2183$$aUniversidad de Zaragoza$$bDpto. Medicina, Psiqu. y Derm.$$cÁrea Dermatología
000089274 773__ $$g9, 2 (2020), 398 [9 pp.]$$pJ. clin.med.$$tJOURNAL OF CLINICAL MEDICINE$$x2077-0383
000089274 8564_ $$s1288457$$uhttps://zaguan.unizar.es/record/89274/files/texto_completo.pdf$$yVersión publicada
000089274 8564_ $$s477286$$uhttps://zaguan.unizar.es/record/89274/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000089274 909CO $$ooai:zaguan.unizar.es:89274$$particulos$$pdriver
000089274 951__ $$a2021-09-02-08:53:20
000089274 980__ $$aARTICLE