Influence of Serum Vitamin D Level in the Response of Actinic Keratosis to Photodynamic Therapy with Methylaminolevulinate

Moreno, Ricardo ; Najera, Laura ; Mascaraque, Marta ; Juarranz, Ángeles ; Gonzalez, Salvador ; Gilaberte, Yolanda (Universidad de Zaragoza)

Resumen: In mouse models of squamous cell carcinoma, pre-treatment with calcitriol prior to photodynamic therapy with aminolevulinic acid (ALA) enhances tumor cell death. We have evaluated the association between vitamin D status and the response of actinic keratoses to photodynamic therapy with methylaminolevulinate. Twenty-five patients with actinic keratoses on the head received one session of photodynamic therapy with methylaminolevulinate. Biopsies were taken at baseline and six weeks after treatment. Immuno-histochemical staining was performed for VDR, P53, Ki67 and beta-catenin. Basal serum 25(OH)D levels were determined. Cases with a positive histological response to treatment had significantly higher serum 25(OH)D levels (26.96 (SD 7.49) ngr/mL) than those without response (18.60 (SE 7.49) ngr/mL) (p = 0.05). Patients with a complete clinical response displayed lower basal VDR expression (35.71% (SD 19.88)) than partial responders (62.78% (SD 16.735)), (p = 0.002). Our results support a relationship between vitamin D status and the response of actinic keratoses to photodynamic therapy with methylaminolevulinate.

Idioma: Inglés

DOI: 10.3390/jcm9020398

Año: 2020

Publicado en: JOURNAL OF CLINICAL MEDICINE 9, 2 (2020), 398 [9 pp.]
ISSN: 2077-0383

Factor impacto JCR: 4.241 (2020)

Categ. JCR: MEDICINE, GENERAL & INTERNAL rank: 39 / 169 = 0.231 (2020) - Q1 - T1

Financiación: info:eu-repo/grantAgreement/ES/ISCIII/PI18-00858

Tipo y forma: Article (Published version)

Área (Departamento): Área Dermatología (Dpto. Medicina, Psiqu. y Derm.)