Influence of Serum Vitamin D Level in the Response of Actinic Keratosis to Photodynamic Therapy with Methylaminolevulinate
Resumen: In mouse models of squamous cell carcinoma, pre-treatment with calcitriol prior to photodynamic therapy with aminolevulinic acid (ALA) enhances tumor cell death. We have evaluated the association between vitamin D status and the response of actinic keratoses to photodynamic therapy with methylaminolevulinate. Twenty-five patients with actinic keratoses on the head received one session of photodynamic therapy with methylaminolevulinate. Biopsies were taken at baseline and six weeks after treatment. Immuno-histochemical staining was performed for VDR, P53, Ki67 and beta-catenin. Basal serum 25(OH)D levels were determined. Cases with a positive histological response to treatment had significantly higher serum 25(OH)D levels (26.96 (SD 7.49) ngr/mL) than those without response (18.60 (SE 7.49) ngr/mL) (p = 0.05). Patients with a complete clinical response displayed lower basal VDR expression (35.71% (SD 19.88)) than partial responders (62.78% (SD 16.735)), (p = 0.002). Our results support a relationship between vitamin D status and the response of actinic keratoses to photodynamic therapy with methylaminolevulinate.
Idioma: Inglés
DOI: 10.3390/jcm9020398
Año: 2020
Publicado en: JOURNAL OF CLINICAL MEDICINE 9, 2 (2020), 398 [9 pp.]
ISSN: 2077-0383

Factor impacto SCIMAGO:

Financiación: info:eu-repo/grantAgreement/ES/ISCIII/PI18-00858
Tipo y forma: Artículo (Versión definitiva)
Área (Departamento): Area Dermatología (Dpto. Medicina, Psiqu. y Derm.)

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