The association of living donor source with patient and graft survival among kidney transplant recipients in the ERA-EDTA Registry – a retrospective study

Abd ElHafeez, S. ; Noordzij, M. ; Kramer, A. ; Bell, S. ; Savoye, E. ; Abad Diez, J.M. (Universidad de Zaragoza) ; Lundgren, T. ; Reisæter, A.V. ; Kerschbaum, J. ; Santiuste de Pablos, C. ; Ortiz, F. ; Collart, F. ; Palsson, R. ; Arici, M. ; Heaf, J.G. ; Massy, Z.A. ; Jager, K.J.

Resumen: In this study we aimed to compare patient and graft survival of kidney transplant recipients who received a kidney from a living-related donor (LRD) or living-unrelated donor (LUD). Adult patients in the ERA-EDTA Registry who received their first kidney transplant in 1998–2017 were included. Ten-year patient and graft survival were compared between LRD and LUD transplants using Cox regression analysis. In total, 14 370 patients received a kidney from a living donor. Of those, 9212 (64.1%) grafts were from a LRD, 5063 (35.2%) from a LUD and for 95 (0.7%), the donor type was unknown. Unadjusted five-year risks of death and graft failure (including death as event) were lower for LRD transplants than for LUD grafts: 4.2% (95% confidence interval [CI]: 3.7–4.6) and 10.8% (95% CI: 10.1–11.5) versus 6.5% (95% CI: 5.7–7.4) and 12.2% (95% CI: 11.2–13.3), respectively. However, after adjusting for potential confounders, associations disappeared with hazard ratios of 0.99 (95% CI: 0.87–1.13) for patient survival and 1.03 (95% CI: 0.94–1.14) for graft survival. Unadjusted risk of death-censored graft failure was similar, but after adjustment, it was higher for LUD transplants (1.19; 95% CI: 1.04–1.35). In conclusion, patient and graft survival of LRD and LUD kidney transplant recipients was similar, whereas death-censored graft failure was higher in LUD. These findings confirm the importance of both living kidney donor types.

Idioma: Inglés

DOI: 10.1111/tri.13759

Año: 2021

Publicado en: TRANSPLANT INTERNATIONAL 34, 1 (2021), 76-86
ISSN: 0934-0874

Factor impacto JCR: 3.842 (2021)

Categ. JCR: SURGERY rank: 46 / 214 = 0.215 (2021) - Q1 - T1
Categ. JCR: TRANSPLANTATION rank: 10 / 26 = 0.385 (2021) - Q2 - T2

Factor impacto CITESCORE: 4.3 - Medicine (Q2)

Factor impacto SCIMAGO: 1.005 - Transplantation (Q1)

Tipo y forma: Artículo (Versión definitiva)

Área (Departamento): Área Medic.Prevent.Salud Públ. (Dpto. Microb.Ped.Radio.Sal.Pú.)