Social history and exposure to pathogen signals modulate social status effects on gene regulation in rhesus macaques

Sanz, J. (Universidad de Zaragoza) ; Maurizio, P.L. ; Snyder-Mackler, N. ; Simons, N.D. ; Voyles, T. ; Kohn, J. ; Michopoulos, V. ; Wilson, M. ; Tung, J. ; Barreiro, L.B.

Resumen: Social experience is an important predictor of disease susceptibility and survival in humans and other social mammals. Chronic social stress is thought to generate a proinflammatory state characterized by elevated antibacterial defenses and reduced investment in antiviral defense. Here we manipulated long-term social status in female rhesus macaques to show that social subordination alters the gene expression response to ex vivo bacterial and viral challenge. As predicted by current models, bacterial lipopolysaccharide polarizes the immune response such that low status corresponds to higher expression of genes in NF-kappa B-dependent proinflammatory pathways and lower expression of genes involved in the antiviral response and type I IFN signaling. Counter to predictions, however, low status drives more exaggerated expression of both NF-kappa B- and IFN-associated genes after cells are exposed to the viral mimic Gardiquimod. Status-driven gene expression patterns are linked not only to social status at the time of sampling, but also to social history (i.e., past social status), especially in unstimulated cells. However, for a subset of genes, we observed interaction effects in which females who fell in rank were more strongly affected by current social status than those who climbed the social hierarchy. Taken together, our results indicate that the effects of social status on immune cell gene expression depend on pathogen exposure, pathogen type, and social history-in support of social experience-mediated biological embedding in adulthood, even in the conventionally memory-less innate immune system.

Idioma: Inglés

DOI: 10.1073/pnas.1820846116

Año: 2020

Publicado en: Proceedings of the National Academy of Sciences of the United States of America 117, 38 (2020), 23317-23322
ISSN: 0027-8424

Factor impacto JCR: 11.205 (2020)

Categ. JCR: MULTIDISCIPLINARY SCIENCES rank: 8 / 73 = 0.11 (2020) - Q1 - T1

Factor impacto SCIMAGO: 5.011 - Multidisciplinary (Q1)

Financiación: info:eu-repo/grantAgreement/ES/MICINN/RYC-2017-23560

Tipo y forma: Artículo (Versión definitiva)

Área (Departamento): Área Física Teórica (Dpto. Física Teórica)