Diagnostic ability of multifocal electroretinogram in early multiple sclerosis using a new signal analysis method
Boquete, L. ; López-Guillén, E. ; Vilades, E. ; Miguel-Jiménez, J.M. ; Pablo, L.E. (Universidad de Zaragoza) ; de Santiago, L. ; del Castillo, M.O. ; Alonso-Rodríguez, M.C. ; Morla, E.M.S. ; López-Dorado, A. ; Garcia-Martin, E. (Universidad de Zaragoza)
Resumen: Purpose
To determine if a novel analysis method will increase the diagnostic value of the multifocal electroretinogram (mfERG) in diagnosing early-stage multiple sclerosis (MS).
Methods
We studied the mfERG signals of OD (Oculus Dexter) eyes of fifteen patients diagnosed with early-stage MS (in all cases < 12 months) and without a history of optic neuritis (ON) (F: M = 11:4), and those of six controls (F:M = 3:3). We obtained values of amplitude and latency of N1 and P1 waves, and a method to assess normalized root-mean-square error (FNRMSE) between model signals and mfERG recordings was used. Responses of each eye were analysed at a global level, and by rings, quadrants and hemispheres. AUC (area under the ROC curve) is used as discriminant factor.
Results
The standard method of analysis obtains further discrimination between controls and MS in ring R3 (AUC = 0.82), analysing N1 waves amplitudes. In all of the retina analysis regions, FNRMSE value shows a greater discriminating power than the standard method. The highest AUC value (AUC = 0.91) was in the superior temporal quadrant.
Conclusion
By analysing mfERG recordings and contrasting them with those of healthy controls it is possible to detect early-stage MS in patients without a previous history of ON.
Idioma: Inglés
DOI: 10.1371/journal.pone.0224500
Año: 2019
Publicado en: PloS one 14, 11 (2019), e0224500 [12 pp]
ISSN: 1932-6203
Factor impacto JCR: 2.74 (2019)
Categ. JCR: MULTIDISCIPLINARY SCIENCES rank: 27 / 71 = 0.38 (2019) - Q2 - T2
Factor impacto SCIMAGO: 1.023 - Multidisciplinary (Q1)
Financiación: info:eu-repo/grantAgreement/ES/ISCIII/PI17-01726
Financiación: info:eu-repo/grantAgreement/ES/ISCIII/RETICS-RD16-0008-020
Financiación: info:eu-repo/grantAgreement/ES/ISCIII/RETICS-RD16-0008-029
Financiación: info:eu-repo/grantAgreement/ES/MINECO-AEI-FEDER/DPI2017-88438-R
Tipo y forma: Artículo (Versión definitiva)
Área (Departamento): Área Oftalmología (Dpto. Cirugía,Ginecol.Obstetr.)
Debe reconocer adecuadamente la autoría, proporcionar un enlace a la licencia e indicar si se han realizado cambios. Puede hacerlo de cualquier manera razonable, pero no de una manera que sugiera que tiene el apoyo del licenciador o lo recibe por el uso que hace.
Exportado de SIDERAL (2021-01-20-10:41:30)
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To determine if a novel analysis method will increase the diagnostic value of the multifocal electroretinogram (mfERG) in diagnosing early-stage multiple sclerosis (MS).
Methods
We studied the mfERG signals of OD (Oculus Dexter) eyes of fifteen patients diagnosed with early-stage MS (in all cases < 12 months) and without a history of optic neuritis (ON) (F: M = 11:4), and those of six controls (F:M = 3:3). We obtained values of amplitude and latency of N1 and P1 waves, and a method to assess normalized root-mean-square error (FNRMSE) between model signals and mfERG recordings was used. Responses of each eye were analysed at a global level, and by rings, quadrants and hemispheres. AUC (area under the ROC curve) is used as discriminant factor.
Results
The standard method of analysis obtains further discrimination between controls and MS in ring R3 (AUC = 0.82), analysing N1 waves amplitudes. In all of the retina analysis regions, FNRMSE value shows a greater discriminating power than the standard method. The highest AUC value (AUC = 0.91) was in the superior temporal quadrant.
Conclusion
By analysing mfERG recordings and contrasting them with those of healthy controls it is possible to detect early-stage MS in patients without a previous history of ON.
Idioma: Inglés
DOI: 10.1371/journal.pone.0224500
Año: 2019
Publicado en: PloS one 14, 11 (2019), e0224500 [12 pp]
ISSN: 1932-6203
Factor impacto JCR: 2.74 (2019)
Categ. JCR: MULTIDISCIPLINARY SCIENCES rank: 27 / 71 = 0.38 (2019) - Q2 - T2
Factor impacto SCIMAGO: 1.023 - Multidisciplinary (Q1)
Financiación: info:eu-repo/grantAgreement/ES/ISCIII/PI17-01726
Financiación: info:eu-repo/grantAgreement/ES/ISCIII/RETICS-RD16-0008-020
Financiación: info:eu-repo/grantAgreement/ES/ISCIII/RETICS-RD16-0008-029
Financiación: info:eu-repo/grantAgreement/ES/MINECO-AEI-FEDER/DPI2017-88438-R
Tipo y forma: Artículo (Versión definitiva)
Área (Departamento): Área Oftalmología (Dpto. Cirugía,Ginecol.Obstetr.)
Debe reconocer adecuadamente la autoría, proporcionar un enlace a la licencia e indicar si se han realizado cambios. Puede hacerlo de cualquier manera razonable, pero no de una manera que sugiera que tiene el apoyo del licenciador o lo recibe por el uso que hace. Exportado de SIDERAL (2021-01-20-10:41:30)
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