Staphylococcus aureus nasal colonization in Spanish children. The COSACO nationwide surveillance study
Del Rosal, T. ; Echevarría, A.M. ; Garcia-Vera, C. (Universidad de Zaragoza) ; Escosa-Garcia, L. ; Agud, M. ; Chaves, F. ; Román, F. ; Gutierrez-Fernandez, J. ; de Gopegui, E.R. ; Ruiz-Carrascoso, G. ; Ruiz-Gallego, M.C. ; Bernet, A. ; Quevedo, S.M. ; Fernández-Verdugo, A.M. ; Díez-Sebastian, J. ; Calvo, C.
Resumen: Objective: To assess the prevalence and risk factors for S. aureus and methicillin-resistant S. aureus (MRSA) nasal colonization in Spanish children.
Methods: Cross-sectional study of patients <14 years from primary care centers all over Spain. Clinical data and nasal aspirates were collected from March to July 2018.
Results: A total of 1876 patients were enrolled. Prevalence of S. aureus and MRSA colonization were 33% (95% CI 30.9–35.1) and 1.44% (95% CI 0.9–2), respectively. Thirtythree percent of the children (633/1876) presented chronic conditions, mainly atopic dermatitis, asthma and/or allergy (524/633). Factors associated with S. aureus colonization were age =5 years (OR 1.10, 95% CI 1.07–1.12), male sex (OR 1.43, 95% CI 1.17–1.76), urban setting (OR 1.46, 95% CI 1.08–1.97) and the presence of asthma, atopic dermatitis or allergies (OR 1.25; 95% CI: 1.093–1.43). Rural residence was the only factor associated with MRSA colonization (OR 3.62, 95% CI 1.57–8.36). MRSA was more frequently resistant than methicillin-susceptible S. aureus to ciprofloxacin [41.2% vs 2.6%; p<0.0001], clindamycin [26% vs 16.9%; p=0.39], and mupirocin [14.3% vs 6.7%; p=0.18]. None of the MRSA strains was resistant to tetracycline, fosfomycin, vancomycin or daptomycin.
Conclusions: The main risk factors for S. aureus colonization in Spanish children are being above five years of age, male gender, atopic dermatitis, asthma or allergy, and residence in urban areas. MRSA colonization is low, but higher than in other European countries and is associated with rural settings.
Idioma: Inglés
DOI: 10.2147/IDR.S282880
Año: 2020
Publicado en: Infection and Drug Resistance 13 (2020), 4643-4651
ISSN: 1178-6973
Factor impacto JCR: 4.003 (2020)
Categ. JCR: PHARMACOLOGY & PHARMACY rank: 111 / 275 = 0.404 (2020) - Q2 - T2
Categ. JCR: INFECTIOUS DISEASES rank: 35 / 92 = 0.38 (2020) - Q2 - T2
Factor impacto SCIMAGO: 1.032 - Infectious Diseases (Q1) - Pharmacology (medical) (Q1) - Pharmacology (Q1)
Financiación: info:eu-repo/grantAgreement/ES/MICINN-ISCIII-FEDER-FIS/PI18CIII-00372
Tipo y forma: Artículo (Versión definitiva)
Área (Departamento): Área Pediatría (Dpto. Microb.Ped.Radio.Sal.Pú.)
Debe reconocer adecuadamente la autoría, proporcionar un enlace a la licencia e indicar si se han realizado cambios. Puede hacerlo de cualquier manera razonable, pero no de una manera que sugiera que tiene el apoyo del licenciador o lo recibe por el uso que hace. No puede utilizar el material para una finalidad comercial.
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Methods: Cross-sectional study of patients <14 years from primary care centers all over Spain. Clinical data and nasal aspirates were collected from March to July 2018.
Results: A total of 1876 patients were enrolled. Prevalence of S. aureus and MRSA colonization were 33% (95% CI 30.9–35.1) and 1.44% (95% CI 0.9–2), respectively. Thirtythree percent of the children (633/1876) presented chronic conditions, mainly atopic dermatitis, asthma and/or allergy (524/633). Factors associated with S. aureus colonization were age =5 years (OR 1.10, 95% CI 1.07–1.12), male sex (OR 1.43, 95% CI 1.17–1.76), urban setting (OR 1.46, 95% CI 1.08–1.97) and the presence of asthma, atopic dermatitis or allergies (OR 1.25; 95% CI: 1.093–1.43). Rural residence was the only factor associated with MRSA colonization (OR 3.62, 95% CI 1.57–8.36). MRSA was more frequently resistant than methicillin-susceptible S. aureus to ciprofloxacin [41.2% vs 2.6%; p<0.0001], clindamycin [26% vs 16.9%; p=0.39], and mupirocin [14.3% vs 6.7%; p=0.18]. None of the MRSA strains was resistant to tetracycline, fosfomycin, vancomycin or daptomycin.
Conclusions: The main risk factors for S. aureus colonization in Spanish children are being above five years of age, male gender, atopic dermatitis, asthma or allergy, and residence in urban areas. MRSA colonization is low, but higher than in other European countries and is associated with rural settings.
Idioma: Inglés
DOI: 10.2147/IDR.S282880
Año: 2020
Publicado en: Infection and Drug Resistance 13 (2020), 4643-4651
ISSN: 1178-6973
Factor impacto JCR: 4.003 (2020)
Categ. JCR: PHARMACOLOGY & PHARMACY rank: 111 / 275 = 0.404 (2020) - Q2 - T2
Categ. JCR: INFECTIOUS DISEASES rank: 35 / 92 = 0.38 (2020) - Q2 - T2
Factor impacto SCIMAGO: 1.032 - Infectious Diseases (Q1) - Pharmacology (medical) (Q1) - Pharmacology (Q1)
Financiación: info:eu-repo/grantAgreement/ES/MICINN-ISCIII-FEDER-FIS/PI18CIII-00372
Tipo y forma: Artículo (Versión definitiva)
Área (Departamento): Área Pediatría (Dpto. Microb.Ped.Radio.Sal.Pú.)
Debe reconocer adecuadamente la autoría, proporcionar un enlace a la licencia e indicar si se han realizado cambios. Puede hacerlo de cualquier manera razonable, pero no de una manera que sugiera que tiene el apoyo del licenciador o lo recibe por el uso que hace. No puede utilizar el material para una finalidad comercial.Exportado de SIDERAL (2021-09-02-11:01:04)
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Artículos > Artículos por área > Pediatría
Registro creado el 2021-02-12, última modificación el 2021-09-02