Virological outcome among HIV infected patients transferred from pediatric care to adult units in Madrid, Spain (1997–2017)

Beltrán-Pavez, C. ; Gutiérrez-López, M. ; Rubio-Garrido, M. ; Valadés-Alcaraz, A. ; Prieto, L. ; Ramos, J.T. ; Jiménez De Ory, S. ; Navarro, M. ; Díez-Romero, C. ; Pulido, F. ; Valencia, E. ; Holguín, Á. ; Mellado, M.J. ; Escosa, L. ; García Hortelano, M. ; Sainz, T. ; González-Tomé, M.I. ; Rojo, P. ; Blázquez, D. ; Prieto-Tato, L. ; Epalza, C. ; Ramos, J.T. ; Guillén, S. ; Navarro, M.L. ; Saavedra, J. ; Santos, M. ; Santiago, B. ; Aguilera-Alonso, D. ; Jiménez De Ory, S. ; Carrasco, I. ; Roa, M.Á. ; Penín, M. ; Martínez, J. ; Badillo, K. ; Oñate, E. ; Pocheville, I. ; Garrote, E. ; Colino, E. ; Gómez Sirvent, J. ; Garzón, M. ; Román, V. ; Angulo, R. ; Neth, O. ; Falcón, L. ; Terol, P. ; Santos, J.L. ; Moreno, D. ; Lendínez, F. ; Peromingo, E. ; Uberos, J. ; Ruiz, B. ; Grande, A. ; Romero, F.J. ; Pérez, C. ; Lillo, M. ; Losada, B. ; Herranz, M. ; Bustillo, M. ; Collado, P. (Universidad de Zaragoza) ; Couceiro, J.A. ; Vila, L. ; Calviño, C. ; Piqueras, A.I. ; Oltra, M. ; Gavilán, C. ; Montesinos, E. ; Dapena, M. ; Álvarez, C. ; Jiménez, B. ; Andrés, A.G. ; Marugán, V. ; Ochoa, C. ; Alfayate, S. ; Menasalvas, A.I. ; Ruiz Del Prado, Y. ; Soler-Palacín, P. ; Frick, M.A. ; Mur, A. ; López, N. ; Méndez, M. ; Mayol, L. ; Vallmanya, T. ; Calavia, O. ; García, L. ; Coll, M.T. ; Pineda, V. ; Rius, N. ; Dueñas, J. ; Fortuny, C. ; Noguera-Julián, A. ; Bernardino, I. ; Montes, M.L. ; Valencia, E. ; Rubio, R. ; Pulido, F. ; Bisbal, O. ; Gaspar Alonso, G. ; Berenguer, J. ; Díez, C. ; Aldamiz, T. ; Montilla, P. ; Bermúdez, E. ; Valerio, M. ; Sanz, J. ; Arponen, S. ; Gimeno, A. ; Cervero, M. ; Torres, R. ; Moreno, S. ; Pérez, M.ªJ. ; Ryan, P. ; Troya, J. ; Sanz, J. ; Losa, J. ; Gómez, R. ; Iribarren, J.A. ; Rodríguez, F. ; Pascual, L. ; Aramburu, M.J. ; Goikoetxea, A.J. ; Aguirrebengoa, L. ; Muñoz, J. ; Ibarra, S. ; Hernández, M. ; Gómez Sirvent, J.L. ; Rodríguez, J. ; Cárdenes, M.Á. ; López-Cortés, L.F. ; Roca, C. ; Llaves, S. ; Ríos, M.J. ; Rodríguez, J. ; Palomo, V. ; Pasquau, J. ; García, C. ; Hernández, J. ; Martínez, C. ; Rivero, A. ; Camacho, Á. ; Merino, D. ; Martínez, E. ; Mateos, F. ; Blanch, J.J. ; Torralba, M. ; Arazo, P. ; Samperiz, G. ; Crusells, M.J. (Universidad de Zaragoza) ; San Joaquín, I. ; Miralles, C. ; Ocampo, A. ; Pousada, G. ; Mena, Á. ; Montero, M. ; Salavert, M. ; Cuéllar, S. ; Galindo, M.J. ; Ferrando, R. ; Portilla, J. ; Portilla, I. ; Gutiérrez, F. ; Masiá, M. ; Robledano, C. ; Adsuar, A. ; Hinojosa, C. ; Bachiller, P. ; Abadía, J. ; Mostaza, J.L. ; Pérez, R. ; Galera, C. ; Albendín, H. ; Pérez, A. ; Blanco, J.R. ; Burgos, J. ; Torres, B. ; Lazzari, E.

Resumen: The aim of this transversal study was to describe the virological and immunological features of HIV-infected youths transferred from pediatric to adult care units since 1997 vs. the non-transferred patients from the Madrid Cohort of HIV-infected children and adolescents in Spain. We included 106 non-transferred and 184 transferred patients under clinical follow-up in 17 public hospitals in Madrid by the end of December 2017. Virological and immunological outcomes were compared in transferred vs. non-transferred patients. ART drug resistance mutations and HIV-variants were analyzed in all subjects with available resistance pol genotypes and/or genotypic resistance profiles. Among the study cohort, 133 (72.3%) of 184 transferred and 75 (70.7%) of 106 non-transferred patients had available resistance genotypes. Most (88.9%) of transferred had ART experience at sampling. A third (33.3%) had had a triple-class experience. Acquired drug resistance (ADR) prevalence was significantly higher in pretreated transferred than non-transferred patients (71.8% vs. 44%; p = 0.0009), mainly to NRTI (72.8% vs. 31.1%; p < 0.0001) and PI (29.1% vs. 12%; p = 0.0262). HIV-1 non-B variants were less frequent in transferred vs. non-transferred (6.9% vs. 32%; p < 0.0001). In conclusion, the frequent resistant genotypes found in transferred youths justifies the reinforcement of HIV resistance monitoring after the transition to avoid future therapeutic failures.

Idioma: Inglés

DOI: 10.1038/s41598-020-70861-x

Año: 2020

Publicado en: Scientific Reports 10, 1 (2020), 16891
ISSN: 2045-2322

Factor impacto JCR: 4.379 (2020)

Categ. JCR: MULTIDISCIPLINARY SCIENCES rank: 17 / 73 = 0.233 (2020) - Q1 - T1

Factor impacto SCIMAGO: 1.24 - Multidisciplinary (Q1)

Financiación: info:eu-repo/grantAgreement/EUR/ERDF/A way to achieve Europe
Financiación: info:eu-repo/grantAgreement/ES/ISCIII-FIS/PI19-01530
Financiación: info:eu-repo/grantAgreement/ES/ISCIII/PI15-01005-RIS-EPICLIN-02-2016
Financiación: info:eu-repo/grantAgreement/ES/MSCBS/CIBERESP
Financiación: info:eu-repo/grantAgreement/ES/MSCBS-ISCIII-FEDER/RD06-0025
Financiación: info:eu-repo/grantAgreement/ES/MSCBS/RIS-EPICLIN-06-2013
Financiación: info:eu-repo/grantAgreement/ES/MSCBS/RIS-EPICLIN-14-2017

Tipo y forma: Artículo (Versión definitiva)

Área (Departamento): Area Medicina (Dpto. Medicina, Psiqu. y Derm.)
Área (Departamento): Área Pediatría (Dpto. Microb.Ped.Radio.Sal.Pú.)