Resumen: Total knee arthroplasty (TKA) is a reliable surgical procedure, yet up to a fifth of primary implant patients remains unsatisfied. Musculoskeletal modeling (MSM) has the potential to explore the relationship between implant alignment and functional outcome [3]. Consequently, implant alignment can be quantitatively optimized to restore the preTKA joint behavior and, therefore, achieve the most favorable functional outcome for the specific patient. For this reason, we developed a method to optimize the implant alignment, with the aim of restoring the native kinematics and ligament elongations of the patient before undergoing TKA. Subject-specific optimization towards ligament elongations demonstrated to accurately emulate the pre-TKA ligament behavior, in contrast to the mechanically aligned approach. However, the values of the optimized implant positions resulting from the pre-TKA kinematic optimization were extreme in some cases. The presented modelling approach is a promising starting point for allowing surgeons to evaluate the patient-specific implant alignment and restore the patientspecific biomechanics. Idioma: Inglés DOI: 10.29007/7dsg Año: 2019 Publicado en: EPiC series in health sciences 3 (2019), 311-314 ISSN: 2398-5305 Tipo y forma: Artículo (Versión definitiva) Área (Departamento): Área Mec.Med.Cont. y Teor.Est. (Dpto. Ingeniería Mecánica)