doi:10.29007/7dsgengQuilez, María PazDelport, Hendrik PieterWirix-Speetjens, RoelWesseling, MariskaPérez Ansón, María de los ÁngelesJonkers, IlseVander Sloten, JosCan standard implants reproduce the native kinematics of a TKA patient?ART-2019-122371Total knee arthroplasty (TKA) is a reliable surgical procedure, yet up to a fifth of primary implant patients remains unsatisfied. Musculoskeletal modeling (MSM) has the potential to explore the relationship between implant alignment and functional outcome [3]. Consequently, implant alignment can be quantitatively optimized to restore the preTKA joint behavior and, therefore, achieve the most favorable functional outcome for the specific patient. For this reason, we developed a method to optimize the implant alignment, with the aim of restoring the native kinematics and ligament elongations of the patient before undergoing TKA. Subject-specific optimization towards ligament elongations demonstrated to accurately emulate the pre-TKA ligament behavior, in contrast to the mechanically aligned approach. However, the values of the optimized implant positions resulting from the pre-TKA kinematic optimization were extreme in some cases. The presented modelling approach is a promising starting point for allowing surgeons to evaluate the patient-specific implant alignment and restore the patientspecific biomechanics.2019http://zaguan.unizar.es/record/10076810.29007/7dsghttp://zaguan.unizar.es/record/100768oai:zaguan.unizar.es:100768EPiC series in health sciences 3 (2019), 311-314byhttp://creativecommons.org/licenses/by/3.0/es/info:eu-repo/semantics/openAccess