000100801 001__ 100801
000100801 005__ 20230519145423.0
000100801 0247_ $$2doi$$a10.1038/s41598-021-82712-4
000100801 0248_ $$2sideral$$a122757
000100801 037__ $$aART-2021-122757
000100801 041__ $$aeng
000100801 100__ $$0(orcid)0000-0001-6899-5938$$aSeral-Cortes, Miguel$$uUniversidad de Zaragoza
000100801 245__ $$aDevelopment of a Genetic Risk Score to predict the risk of overweight and obesity in European adolescents from the HELENA study
000100801 260__ $$c2021
000100801 5060_ $$aAccess copy available to the general public$$fUnrestricted
000100801 5203_ $$aObesity is the result of interactions between genes and environmental factors. Since monogenic etiology is only known in some obesity-related genes, a genetic risk score (GRS) could be useful to determine the genetic predisposition to obesity. Therefore, the aim of our study was to build a GRS able to predict genetic predisposition to overweight and obesity in European adolescents. A total of 1069 adolescents (51.3% female), aged 11–19 years participating in the Healthy Lifestyle in Europe by Nutrition in Adolescence (HELENA) cross-sectional study were genotyped. The sample was divided in non-overweight (non-OW) and overweight/obesity (OW/OB). From 611 single nucleotide polymorphisms (SNP) available, a first screening of 104 SNPs univariately associated with obesity (p < 0.20) was established selecting 21 significant SNPs (p < 0.05) in the multivariate model. Unweighted GRS (uGRS) was calculated by summing the number of risk alleles and weighted GRS (wGRS) by multiplying the risk alleles to each estimated coefficient. The area under curve (AUC) was calculated in uGRS (0.723) and wGRS (0.734) using tenfold internal cross-validation. Both uGRS and wGRS were significantly associated with body mass index (BMI) (p < .001). Both GRSs could potentially be considered as useful genetic tools to evaluate individual’s predisposition to overweight/obesity in European adolescents
000100801 536__ $$9info:eu-repo/grantAgreement/ES/CIBERObn/CB15-00043$$9info:eu-repo/grantAgreement/EC/FP6/7034 /EU/Healthy Lifestyle in Europe by Nutrition in Adolescence/HELENA$$9info:eu-repo/grantAgreement/EC/H2020/801586/EU/International Doctoral Programme for Talent Attraction to the Campus of International Excellence of the Ebro Valley/IberusTalent$$9This project has received funding from the European Union’s Horizon 2020 research and innovation program under grant agreement No H2020 801586-IberusTalent$$9info:eu-repo/grantAgreement/ES/MINECO/RYC-2010-05957$$9info:eu-repo/grantAgreement/ES/MINECO/RYC-2011-09011
000100801 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000100801 590__ $$a4.997$$b2021
000100801 592__ $$a1.005$$b2021
000100801 591__ $$aMULTIDISCIPLINARY SCIENCES$$b19 / 74 = 0.257$$c2021$$dQ2$$eT1
000100801 593__ $$aMultidisciplinary$$c2021$$dQ1
000100801 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000100801 700__ $$aSabroso-Lasa, Sergio
000100801 700__ $$0(orcid)0000-0001-6173-5850$$aDe Miguel-Etayo, Pilar
000100801 700__ $$aGonzalez-Gross, Marcel
000100801 700__ $$aGesteiro, Eva
000100801 700__ $$aMolina-Hidalgo, Cristina
000100801 700__ $$aDe Henauw, Stefaan
000100801 700__ $$aGottrand, Frederic
000100801 700__ $$aMavrogianni, Christina
000100801 700__ $$aManios, Yannis
000100801 700__ $$aPlada, Maria
000100801 700__ $$aWidhalm, Kurt
000100801 700__ $$aKafatos, Anthony
000100801 700__ $$aErhardt, Éva
000100801 700__ $$aMeirhaeghe, Aline
000100801 700__ $$aSalazar-Tortosa, Diego
000100801 700__ $$aRuiz, Jonatan
000100801 700__ $$0(orcid)0000-0003-0454-653X$$aMoreno, Luis A.$$uUniversidad de Zaragoza
000100801 700__ $$0(orcid)0000-0002-3007-302X$$aEsteban, Luis Mariano
000100801 700__ $$aLabayen, Idoia
000100801 7102_ $$11006$$2255$$aUniversidad de Zaragoza$$bDpto. Fisiatría y Enfermería$$cÁrea Enfermería
000100801 773__ $$g11 (2021), 3067 [11 pp.]$$pSci. rep. (Nat. Publ. Group)$$tScientific reports (Nature Publishing Group)$$x2045-2322
000100801 8564_ $$s1349305$$uhttps://zaguan.unizar.es/record/100801/files/texto_completo.pdf$$yVersión publicada
000100801 8564_ $$s2479662$$uhttps://zaguan.unizar.es/record/100801/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000100801 909CO $$ooai:zaguan.unizar.es:100801$$particulos$$pdriver
000100801 951__ $$a2023-05-18-14:10:02
000100801 980__ $$aARTICLE