100801 20230519145423.0 doi 10.1038/s41598-021-82712-4 sideral 122757 ART-2021-122757 eng Seral-Cortes, Miguel Universidad de Zaragoza (orcid)0000-0001-6899-5938 Development of a Genetic Risk Score to predict the risk of overweight and obesity in European adolescents from the HELENA study 2021 Access copy available to the general public Unrestricted Obesity is the result of interactions between genes and environmental factors. Since monogenic etiology is only known in some obesity-related genes, a genetic risk score (GRS) could be useful to determine the genetic predisposition to obesity. Therefore, the aim of our study was to build a GRS able to predict genetic predisposition to overweight and obesity in European adolescents. A total of 1069 adolescents (51.3% female), aged 11–19 years participating in the Healthy Lifestyle in Europe by Nutrition in Adolescence (HELENA) cross-sectional study were genotyped. The sample was divided in non-overweight (non-OW) and overweight/obesity (OW/OB). From 611 single nucleotide polymorphisms (SNP) available, a first screening of 104 SNPs univariately associated with obesity (p < 0.20) was established selecting 21 significant SNPs (p < 0.05) in the multivariate model. Unweighted GRS (uGRS) was calculated by summing the number of risk alleles and weighted GRS (wGRS) by multiplying the risk alleles to each estimated coefficient. The area under curve (AUC) was calculated in uGRS (0.723) and wGRS (0.734) using tenfold internal cross-validation. Both uGRS and wGRS were significantly associated with body mass index (BMI) (p < .001). Both GRSs could potentially be considered as useful genetic tools to evaluate individual’s predisposition to overweight/obesity in European adolescents info:eu-repo/grantAgreement/ES/CIBERObn/CB15-00043 info:eu-repo/grantAgreement/EC/FP6/7034 /EU/Healthy Lifestyle in Europe by Nutrition in Adolescence/HELENA info:eu-repo/grantAgreement/EC/H2020/801586/EU/International Doctoral Programme for Talent Attraction to the Campus of International Excellence of the Ebro Valley/IberusTalent This project has received funding from the European Union’s Horizon 2020 research and innovation program under grant agreement No H2020 801586-IberusTalent info:eu-repo/grantAgreement/ES/MINECO/RYC-2010-05957 info:eu-repo/grantAgreement/ES/MINECO/RYC-2011-09011 info:eu-repo/semantics/openAccess by http://creativecommons.org/licenses/by/3.0/es/ 4.997 2021 MULTIDISCIPLINARY SCIENCES 19 / 74 = 0.257 2021 Q2 T1 1.005 2021 Multidisciplinary 2021 Q1 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Sabroso-Lasa, Sergio De Miguel-Etayo, Pilar (orcid)0000-0001-6173-5850 Gonzalez-Gross, Marcel Gesteiro, Eva Molina-Hidalgo, Cristina De Henauw, Stefaan Gottrand, Frederic Mavrogianni, Christina Manios, Yannis Plada, Maria Widhalm, Kurt Kafatos, Anthony Erhardt, Éva Meirhaeghe, Aline Salazar-Tortosa, Diego Ruiz, Jonatan Moreno, Luis A. Universidad de Zaragoza (orcid)0000-0003-0454-653X Esteban, Luis Mariano (orcid)0000-0002-3007-302X Labayen, Idoia 1006 255 Universidad de Zaragoza Dpto. Fisiatría y Enfermería Área Enfermería 11 (2021), 3067 [11 pp.] Sci. rep. (Nat. Publ. Group) Scientific reports (Nature Publishing Group) 2045-2322 1349305 http://zaguan.unizar.es/record/100801/files/texto_completo.pdf Versión publicada 2479662 http://zaguan.unizar.es/record/100801/files/texto_completo.jpg?subformat=icon icon Versión publicada oai:zaguan.unizar.es:100801 articulos driver 2023-05-18-14:10:02 ARTICLE