000101532 001__ 101532
000101532 005__ 20230622083316.0
000101532 0247_ $$2doi$$a10.1021/acsabm.0c00419
000101532 0248_ $$2sideral$$a118331
000101532 037__ $$aART-2020-118331
000101532 041__ $$aeng
000101532 100__ $$0(orcid)0000-0002-0595-5514$$aGarcía-Salinas, S.$$uUniversidad de Zaragoza
000101532 245__ $$aEfficiency of Antimicrobial Electrospun Thymol-Loaded Polycaprolactone Mats in Vivo
000101532 260__ $$c2020
000101532 5060_ $$aAccess copy available to the general public$$fUnrestricted
000101532 5203_ $$aDue to the prevalence of antimicrobial resistant pathogens, natural products with long-term antimicrobial activities are considered as potential alternatives. In this work, polycaprolactone (PCL) electrospun fibers with mean diameters around 299 nm and loaded with 14.92 ± 1.31% w/w thymol (THY) were synthesized. The mats had appropriate elongation at break (74.4 ± 9.5%) and tensile strength (3.0 ± 0.5 MPa) to be potentially used as wound dressing materials. In vivo studies were performed using eight to ten week-old male SKH1 hairless mice. The infection progression was evaluated through a semiquantitative method and quantitative polymerase chain reaction. The analyses of post-mortem samples indicated that THY-loaded PCL fibers acted as inhibitors of Staphylococcus aureus ATCC 25923 strain growth being as efficient as chlorhexidine (CLXD). Histopathological and immunohistochemical studies showed that the PCL-THY-treated wounds were almost free of an inflammatory reaction. Therefore, wound dressings containing natural compounds can prevent infection and promote wound healing and prompt regeneration. Copyright
000101532 536__ $$9info:eu-repo/grantAgreement/EUR/ERC-2013-CoG-614715$$9info:eu-repo/grantAgreement/ES/MINECO/CTQ2014-52384-R
000101532 540__ $$9info:eu-repo/semantics/openAccess$$aAll rights reserved$$uhttp://www.europeana.eu/rights/rr-f/
000101532 592__ $$a0.764$$b2020
000101532 593__ $$aBiochemistry (medical)$$c2020$$dQ1
000101532 593__ $$aChemistry (miscellaneous)$$c2020$$dQ1
000101532 593__ $$aBiomedical Engineering$$c2020$$dQ1
000101532 593__ $$aBiomaterials$$c2020$$dQ1
000101532 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/acceptedVersion
000101532 700__ $$0(orcid)0000-0002-0272-3152$$aGámez, E.
000101532 700__ $$aAsín, J.
000101532 700__ $$aDe Miguel, R.$$uUniversidad de Zaragoza
000101532 700__ $$0(orcid)0000-0002-6275-1104$$aAndreu, V.
000101532 700__ $$0(orcid)0000-0001-8762-5457$$aSancho-Albero, M.$$uUniversidad de Zaragoza
000101532 700__ $$0(orcid)0000-0003-2293-363X$$aMendoza, G.$$uUniversidad de Zaragoza
000101532 700__ $$0(orcid)0000-0002-2966-9088$$aIrusta, S.$$uUniversidad de Zaragoza
000101532 700__ $$0(orcid)0000-0003-3165-0156$$aArruebo, M.$$uUniversidad de Zaragoza
000101532 7102_ $$11009$$2773$$aUniversidad de Zaragoza$$bDpto. Patología Animal$$cÁrea Sanidad Animal
000101532 7102_ $$15005$$2555$$aUniversidad de Zaragoza$$bDpto. Ing.Quím.Tecnol.Med.Amb.$$cÁrea Ingeniería Química
000101532 7102_ $$15005$$2790$$aUniversidad de Zaragoza$$bDpto. Ing.Quím.Tecnol.Med.Amb.$$cÁrea Tecnologi. Medio Ambiente
000101532 773__ $$g3, 5 (2020), 3430-3439$$pACS appl. bio mater.$$tACS Applied Bio Materials$$x2576-6422
000101532 8564_ $$s575021$$uhttps://zaguan.unizar.es/record/101532/files/texto_completo.pdf$$yPostprint
000101532 8564_ $$s1603181$$uhttps://zaguan.unizar.es/record/101532/files/texto_completo.jpg?subformat=icon$$xicon$$yPostprint
000101532 909CO $$ooai:zaguan.unizar.es:101532$$particulos$$pdriver
000101532 951__ $$a2023-06-21-15:02:12
000101532 980__ $$aARTICLE