101532 20230622083316.0 doi 10.1021/acsabm.0c00419 sideral 118331 ART-2020-118331 eng García-Salinas, S. Universidad de Zaragoza (orcid)0000-0002-0595-5514 Efficiency of Antimicrobial Electrospun Thymol-Loaded Polycaprolactone Mats in Vivo 2020 Access copy available to the general public Unrestricted Due to the prevalence of antimicrobial resistant pathogens, natural products with long-term antimicrobial activities are considered as potential alternatives. In this work, polycaprolactone (PCL) electrospun fibers with mean diameters around 299 nm and loaded with 14.92 ± 1.31% w/w thymol (THY) were synthesized. The mats had appropriate elongation at break (74.4 ± 9.5%) and tensile strength (3.0 ± 0.5 MPa) to be potentially used as wound dressing materials. In vivo studies were performed using eight to ten week-old male SKH1 hairless mice. The infection progression was evaluated through a semiquantitative method and quantitative polymerase chain reaction. The analyses of post-mortem samples indicated that THY-loaded PCL fibers acted as inhibitors of Staphylococcus aureus ATCC 25923 strain growth being as efficient as chlorhexidine (CLXD). Histopathological and immunohistochemical studies showed that the PCL-THY-treated wounds were almost free of an inflammatory reaction. Therefore, wound dressings containing natural compounds can prevent infection and promote wound healing and prompt regeneration. Copyright info:eu-repo/grantAgreement/EUR/ERC-2013-CoG-614715 info:eu-repo/grantAgreement/ES/MINECO/CTQ2014-52384-R info:eu-repo/semantics/openAccess All rights reserved http://www.europeana.eu/rights/rr-f/ 0.764 2020 Biochemistry (medical) 2020 Q1 Chemistry (miscellaneous) 2020 Q1 Biomedical Engineering 2020 Q1 Biomaterials 2020 Q1 info:eu-repo/semantics/article info:eu-repo/semantics/acceptedVersion Gámez, E. (orcid)0000-0002-0272-3152 Asín, J. De Miguel, R. Universidad de Zaragoza Andreu, V. (orcid)0000-0002-6275-1104 Sancho-Albero, M. Universidad de Zaragoza (orcid)0000-0001-8762-5457 Mendoza, G. Universidad de Zaragoza (orcid)0000-0003-2293-363X Irusta, S. Universidad de Zaragoza (orcid)0000-0002-2966-9088 Arruebo, M. Universidad de Zaragoza (orcid)0000-0003-3165-0156 1009 773 Universidad de Zaragoza Dpto. Patología Animal Área Sanidad Animal 5005 555 Universidad de Zaragoza Dpto. Ing.Quím.Tecnol.Med.Amb. Área Ingeniería Química 5005 790 Universidad de Zaragoza Dpto. Ing.Quím.Tecnol.Med.Amb. Área Tecnologi. Medio Ambiente 3, 5 (2020), 3430-3439 ACS appl. bio mater. ACS Applied Bio Materials 2576-6422 575021 http://zaguan.unizar.es/record/101532/files/texto_completo.pdf Postprint 1603181 http://zaguan.unizar.es/record/101532/files/texto_completo.jpg?subformat=icon icon Postprint oai:zaguan.unizar.es:101532 articulos driver 2023-06-21-15:02:12 ARTICLE