000101545 001__ 101545
000101545 005__ 20230519145357.0
000101545 0247_ $$2doi$$a10.3390/jcm10050899
000101545 0248_ $$2sideral$$a124017
000101545 037__ $$aART-2021-124017
000101545 041__ $$aeng
000101545 100__ $$0(orcid)0000-0002-8328-9836$$aJosa-Laorden, Claudia$$uUniversidad de Zaragoza
000101545 245__ $$aGender-based differences by age range in patients hospitalized with covid-19: A Spanish observational cohort study
000101545 260__ $$c2021
000101545 5060_ $$aAccess copy available to the general public$$fUnrestricted
000101545 5203_ $$aThere is some evidence that male gender could have a negative impact on the prognosis and severity of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. The aim of the present study was to compare the characteristics of coronavirus disease 2019 (COVID-19) between hospitalized men and women with confirmed SARS-CoV-2 infection. This multicenter, retrospective, observational study is based on the SEMI-COVID-19 Registry. We analyzed the differences between men and women for a wide variety of demographic, clinical, and treatment variables, and the sex distribution of the reported COVID-19 deaths, as well as intensive care unit (ICU) admission by age subgroups. This work analyzed 12, 063 patients (56.8% men). The women in our study were older than the men, on average (67.9 vs. 65.7 years; p < 001). Bilateral condensation was more frequent among men than women (31.8% vs. 29.9%; p = 0.007). The men needed non-invasive and invasive mechanical ventilation more frequently (5.6% vs. 3.6%, p < 0.001, and 7.9% vs. 4.8%, p < 0.001, respectively). The most prevalent complication was acute respiratory distress syndrome, with severe cases in 19.9% of men (p < 0.001). In men, intensive care unit admission was more frequent (10% vs. 6.1%; p < 0.001) and the mortality rate was higher (23.1% vs. 18.9%; p < 0.001). Regarding mortality, the differences by gender were statistically significant in the age groups from 55 years to 89 years of age. A multivariate analysis showed that female sex was significantly and independently associated with a lower risk of mortality in our study. Male sex appears to be related to worse progress in COVID-19 patients and is an independent prognostic factor for mortality. In order to fully understand its prognostic impact, other factors associated with sex must be considered.
000101545 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000101545 590__ $$a4.964$$b2021
000101545 592__ $$a1.04$$b2021
000101545 594__ $$a4.4$$b2021
000101545 591__ $$aMEDICINE, GENERAL & INTERNAL$$b55 / 172 = 0.32$$c2021$$dQ2$$eT1
000101545 593__ $$aMedicine (miscellaneous)$$c2021$$dQ1
000101545 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000101545 700__ $$aCrestelo-Vieitez, Anxela$$uUniversidad de Zaragoza
000101545 700__ $$aGarcía Andreu, María del Mar$$uUniversidad de Zaragoza
000101545 700__ $$aRubio-Rivas, Manuel
000101545 700__ $$aSánchez, Marcos
000101545 700__ $$aToledo Samaniego, Neera
000101545 700__ $$aArnalich Fernández, Francisco
000101545 700__ $$aIguaran Bermudez, Rosario
000101545 700__ $$aFonseca Aizpuru, Eva María
000101545 700__ $$aVargas Núñez, Juan Antonio
000101545 700__ $$aPesqueira Fontan, Paula María
000101545 700__ $$aSerrano Ballesteros, Jorge
000101545 700__ $$aFreire Castro, Santiago Jesús
000101545 700__ $$aPestaña Fernández, Melania
000101545 700__ $$aViana García, Alba
000101545 700__ $$aNuñez Rodriguez, Victoria
000101545 700__ $$aGiner-Galvan, Vicente
000101545 700__ $$aCarrasco Sánchez, Francisco Javier
000101545 700__ $$aHernández Millán, Almudena
000101545 700__ $$aCobos-Siles, Marta
000101545 700__ $$aNapal Lecumberri, José Javier
000101545 700__ $$aHerrero García, Virginia
000101545 700__ $$aPascual Pérez, María de los Reyes
000101545 700__ $$aMillán Núñez-Cortés, Jesús
000101545 700__ $$aCasas Rojo, José Manuel
000101545 7102_ $$11007$$2610$$aUniversidad de Zaragoza$$bDpto. Medicina, Psiqu. y Derm.$$cArea Medicina
000101545 773__ $$g10, 5 (2021), [21 pp.]$$pJ. clin.med.$$tJournal of Clinical Medicine$$x2077-0383
000101545 8564_ $$s1845906$$uhttps://zaguan.unizar.es/record/101545/files/texto_completo.pdf$$yVersión publicada
000101545 8564_ $$s2902156$$uhttps://zaguan.unizar.es/record/101545/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000101545 909CO $$ooai:zaguan.unizar.es:101545$$particulos$$pdriver
000101545 951__ $$a2023-05-18-13:34:45
000101545 980__ $$aARTICLE