000101616 001__ 101616
000101616 005__ 20240109134257.0
000101616 0247_ $$2doi$$a10.1038/s41598-021-83964-w
000101616 0248_ $$2sideral$$a123928
000101616 037__ $$aART-2021-123928
000101616 041__ $$aeng
000101616 100__ $$aCarmona-Pírez, J.
000101616 245__ $$aMultimorbidity clusters in patients with chronic obstructive airway diseases in the EpiChron Cohort
000101616 260__ $$c2021
000101616 5060_ $$aAccess copy available to the general public$$fUnrestricted
000101616 5203_ $$aChronic obstructive airway diseases such as chronic obstructive pulmonary disease (COPD), asthma, rhinitis, and obstructive sleep apnea (OSA) are amongst the most common treatable and preventable chronic conditions with high morbidity burden and mortality risk. We aimed to explore the existence of multimorbidity clusters in patients with such diseases and to estimate their prevalence and impact on mortality. We conducted an observational retrospective study in the EpiChron Cohort (Aragon, Spain), selecting all patients with a diagnosis of allergic rhinitis, asthma, COPD, and/or OSA. The study population was stratified by age (i.e., 15–44, 45–64, and = 65 years) and gender. We performed cluster analysis, including all chronic conditions recorded in primary care electronic health records and hospital discharge reports. More than 75% of the patients had multimorbidity (co-existence of two or more chronic conditions). We identified associations of dermatologic diseases with musculoskeletal disorders and anxiety, cardiometabolic diseases with mental health problems, and substance use disorders with neurologic diseases and neoplasms, amongst others. The number and complexity of the multimorbidity clusters increased with age in both genders. The cluster with the highest likelihood of mortality was identified in men aged 45 to 64 years and included associations between substance use disorder, neurologic conditions, and cancer. Large-scale epidemiological studies like ours could be useful when planning healthcare interventions targeting patients with chronic obstructive airway diseases and multimorbidity.
000101616 536__ $$9info:eu-repo/grantAgreement/ES/DGA-FEDER/Construyendo Europa desde Aragón$$9info:eu-repo/grantAgreement/ES/IISA-ISCIII/CM19-00164
000101616 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000101616 590__ $$a4.997$$b2021
000101616 592__ $$a1.005$$b2021
000101616 591__ $$aMULTIDISCIPLINARY SCIENCES$$b19 / 74 = 0.257$$c2021$$dQ2$$eT1
000101616 593__ $$aMultidisciplinary$$c2021$$dQ1
000101616 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000101616 700__ $$0(orcid)0000-0002-5119-5093$$aPoblador-Plou, B.
000101616 700__ $$aIoakeim-Skoufa, I.
000101616 700__ $$aGonzález-Rubio, F.
000101616 700__ $$0(orcid)0000-0003-2928-6623$$aGimeno-Feliú, L.A.$$uUniversidad de Zaragoza
000101616 700__ $$0(orcid)0000-0002-3132-2171$$aDíez-Manglano, J.$$uUniversidad de Zaragoza
000101616 700__ $$aLaguna-Berna, C.
000101616 700__ $$aMarin, J.M.
000101616 700__ $$0(orcid)0000-0002-5440-1710$$aGimeno-Miguel, A.
000101616 700__ $$0(orcid)0000-0003-2580-2002$$aPrados-Torres, A.
000101616 7102_ $$11007$$2610$$aUniversidad de Zaragoza$$bDpto. Medicina, Psiqu. y Derm.$$cArea Medicina
000101616 773__ $$g11, 1 (2021), 4784 [9 pp]$$pSci. rep. (Nat. Publ. Group)$$tScientific reports (Nature Publishing Group)$$x2045-2322
000101616 8564_ $$s1098538$$uhttps://zaguan.unizar.es/record/101616/files/texto_completo.pdf$$yVersión publicada
000101616 8564_ $$s2649109$$uhttps://zaguan.unizar.es/record/101616/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000101616 909CO $$ooai:zaguan.unizar.es:101616$$particulos$$pdriver
000101616 951__ $$a2024-01-09-13:33:39
000101616 980__ $$aARTICLE