101616 20250124145431.0 doi 10.1038/s41598-021-83964-w sideral 123928 ART-2021-123928 eng Carmona-Pírez, J. Multimorbidity clusters in patients with chronic obstructive airway diseases in the EpiChron Cohort 2021 Access copy available to the general public Unrestricted Chronic obstructive airway diseases such as chronic obstructive pulmonary disease (COPD), asthma, rhinitis, and obstructive sleep apnea (OSA) are amongst the most common treatable and preventable chronic conditions with high morbidity burden and mortality risk. We aimed to explore the existence of multimorbidity clusters in patients with such diseases and to estimate their prevalence and impact on mortality. We conducted an observational retrospective study in the EpiChron Cohort (Aragon, Spain), selecting all patients with a diagnosis of allergic rhinitis, asthma, COPD, and/or OSA. The study population was stratified by age (i.e., 15–44, 45–64, and = 65 years) and gender. We performed cluster analysis, including all chronic conditions recorded in primary care electronic health records and hospital discharge reports. More than 75% of the patients had multimorbidity (co-existence of two or more chronic conditions). We identified associations of dermatologic diseases with musculoskeletal disorders and anxiety, cardiometabolic diseases with mental health problems, and substance use disorders with neurologic diseases and neoplasms, amongst others. The number and complexity of the multimorbidity clusters increased with age in both genders. The cluster with the highest likelihood of mortality was identified in men aged 45 to 64 years and included associations between substance use disorder, neurologic conditions, and cancer. Large-scale epidemiological studies like ours could be useful when planning healthcare interventions targeting patients with chronic obstructive airway diseases and multimorbidity. info:eu-repo/grantAgreement/ES/DGA-FEDER/B01-20R info:eu-repo/grantAgreement/ES/DGA-FEDER/Construyendo Europa desde Aragón info:eu-repo/grantAgreement/ES/IISA-ISCIII/CM19-00164 info:eu-repo/semantics/openAccess by http://creativecommons.org/licenses/by/3.0/es/ 4.997 2021 MULTIDISCIPLINARY SCIENCES 19 / 74 = 0.257 2021 Q2 T1 1.005 2021 Multidisciplinary 2021 Q1 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Poblador-Plou, B. (orcid)0000-0002-5119-5093 Ioakeim-Skoufa, I. González-Rubio, F. (orcid)0000-0003-2580-2002 Gimeno-Feliú, L.A. Universidad de Zaragoza (orcid)0000-0003-2928-6623 Díez-Manglano, J. Universidad de Zaragoza (orcid)0000-0002-3132-2171 Laguna-Berna, C. Marin, J.M. Universidad de Zaragoza (orcid)0000-0001-9096-2294 Gimeno-Miguel, A. (orcid)0000-0002-5440-1710 Prados-Torres, A. (orcid)0000-0002-5704-6056 1007 610 Universidad de Zaragoza Dpto. Medicina, Psiqu. y Derm. Area Medicina 11 (2021), 4784 [9 pp.] Sci. rep. (Nat. Publ. Group) Scientific reports (Nature Publishing Group) 2045-2322 1098538 http://zaguan.unizar.es/record/101616/files/texto_completo.pdf Versión publicada 2649109 http://zaguan.unizar.es/record/101616/files/texto_completo.jpg?subformat=icon icon Versión publicada oai:zaguan.unizar.es:101616 articulos driver 2025-01-24-14:51:13 ARTICLE