000101630 001__ 101630 000101630 005__ 20230519145428.0 000101630 0247_ $$2doi$$a10.1016/j.ejogrb.2021.03.007 000101630 0248_ $$2sideral$$a123968 000101630 037__ $$aART-2021-123968 000101630 041__ $$aeng 000101630 100__ $$0(orcid)0000-0002-2801-416X$$aPérez-López, F.R. 000101630 245__ $$aCirculating kisspeptin and anti-müllerian hormone levels, and insulin resistance in women with polycystic ovary syndrome: a systematic review, meta-analysis, and meta-regression 000101630 260__ $$c2021 000101630 5060_ $$aAccess copy available to the general public$$fUnrestricted 000101630 5203_ $$aObjective: This systematic review and meta-analysis aimed to summarize the available evidence regarding circulating kisspeptin and anti-müllerian hormone (AMH) and the homeostasis model assessment of insulin resistance (HOMA-IR) index in adolescents and women with and without polycystic ovary syndrome (PCOS). Method: We performed a comprehensive literature search in Medline, Embase, Cochrane, Scopus, and Web of Science for studies evaluating circulating kisspeptin levels in women with and without PCOS published until September 24th, 2020. Co-primary outcomes were the HOMA-IR index and AMH. The quality of included studies was assessed using the Newcastle-Ottawa Scale. Random-effects models were used to estimate outcomes, and effects reported as mean difference (MD) or standardized MD (SMD) and their 95 % confidence interval (CI). The systematic review and meta-analysis was registered in the International Prospective Register of Systematic Reviews (PROSPERO) as number CRD42020205030. Results: We evaluated 18 studies including, 1282 PCOS cases and 977 controls. Participants with PCOS were younger (MD = −2.38 years, 95 %CI -4.32 to -0.44), with higher BMI (MD = 1.16, 95 % CI 0.54–1.78), waist-to-hip ratio (MD = 0.04, 95 %CI 0.02 to 0.05), circulating kisspeptin (SMD = 1.15, 95 %CI 0.68–1.62), luteinizing hormone (SMD = 1.29, 95 %CI 0.76–1.83), AMH (SMD = 0.97, 95 %CI 0.60–1,34), total testosterone (SMD = 2.48, 95 %CI 1.73–3.23), free testosterone (SMD = 1.37, 95 %CI 0.56–2.17), and dehydroepiandrosterone sulphate (SMD = 0.72, 95 %CI 0.32–1.13) levels, and Ferriman-Gallwey score (SMD = 5.08, 95 %CI 2.76–7.39), and lower sex hormone-binding globulin level (SMD = −1.34, 95 %CI −2.15 to −0.52). Besides, participants with PCOS had higher HOMA-IR index (SMD = 0.76, 95 %CI 0.35–1.17), and circulating insulin (SMD = 0.75, 95 %CI 0.30–1.19), leptin (SMD = 2.82, 95 %CI 1.35–4.29), and triglycerides (SMD = 2.15, 95 %CI 1.08–3.23) levels than participants without the syndrome. The meta-regression did not identify significant factors influencing circulating kisspeptin. Conclusion: Patients with PCOS showed higher kisspeptin, LH, insulin, AMH, and androgen levels and HOMA-IR index, and lower sex hormone-binding globulin levels than those without the syndrome. 000101630 540__ $$9info:eu-repo/semantics/openAccess$$aby-nc-nd$$uhttp://creativecommons.org/licenses/by-nc-nd/3.0/es/ 000101630 590__ $$a2.831$$b2021 000101630 592__ $$a0.635$$b2021 000101630 594__ $$a3.3$$b2021 000101630 591__ $$aREPRODUCTIVE BIOLOGY$$b21 / 31 = 0.677$$c2021$$dQ3$$eT3 000101630 593__ $$aReproductive Medicine$$c2021$$dQ2 000101630 591__ $$aOBSTETRICS & GYNECOLOGY$$b46 / 85 = 0.541$$c2021$$dQ3$$eT2 000101630 593__ $$aObstetrics and Gynecology$$c2021$$dQ2 000101630 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/acceptedVersion 000101630 700__ $$0(orcid)0000-0001-9056-2143$$aOrnat, L.$$uUniversidad de Zaragoza 000101630 700__ $$aLópez-Baena, M.T. 000101630 700__ $$0(orcid)0000-0002-7297-6104$$aSantabárbara, J.$$uUniversidad de Zaragoza 000101630 700__ $$0(orcid)0000-0001-9585-0187$$aSavirón Cornudella, R.$$uUniversidad de Zaragoza 000101630 700__ $$aPérez Roncero, G.R.$$uUniversidad de Zaragoza 000101630 7102_ $$11006$$2255$$aUniversidad de Zaragoza$$bDpto. Fisiatría y Enfermería$$cÁrea Enfermería 000101630 7102_ $$11003$$2027$$aUniversidad de Zaragoza$$bDpto. Anatom.Histolog.Humanas$$cArea Anatom.Embriol.Humana 000101630 7102_ $$11013$$2645$$aUniversidad de Zaragoza$$bDpto. Cirugía$$cÁrea Obstetricia y Ginecología 000101630 7102_ $$11011$$2615$$aUniversidad de Zaragoza$$bDpto. Microb.Ped.Radio.Sal.Pú.$$cÁrea Medic.Prevent.Salud Públ. 000101630 773__ $$g260 (2021), 85-98$$pEur. j. obstet., gynecol., reprod. biol.$$tEuropean Journal of Obstetrics and Gynecology and Reproductive Biology$$x0301-2115 000101630 8564_ $$s1769496$$uhttps://zaguan.unizar.es/record/101630/files/texto_completo.pdf$$yPostprint 000101630 8564_ $$s1243626$$uhttps://zaguan.unizar.es/record/101630/files/texto_completo.jpg?subformat=icon$$xicon$$yPostprint 000101630 909CO $$ooai:zaguan.unizar.es:101630$$particulos$$pdriver 000101630 951__ $$a2023-05-18-14:14:41 000101630 980__ $$aARTICLE