000101640 001__ 101640 000101640 005__ 20230519145441.0 000101640 0247_ $$2doi$$a10.3390/nu13030723 000101640 0248_ $$2sideral$$a124114 000101640 037__ $$aART-2021-124114 000101640 041__ $$aeng 000101640 100__ $$0(orcid)0000-0002-7194-8275$$aMalo, Sara$$uUniversidad de Zaragoza 000101640 245__ $$aIdentifying clusters of adherence to cardiovascular risk reduction behaviors and persistence with medication in new lipid-lowering drug users. Impact on healthcare utilization 000101640 260__ $$c2021 000101640 5060_ $$aAccess copy available to the general public$$fUnrestricted 000101640 5203_ $$aWe sought to identify specific profiles of new lipid-lowering drug users based on adherence to a healthy lifestyle and persistence with medication, and to characterize co-morbidities, co-treatments, and healthcare utilization for each of the profiles identified. Observational study in 517 participants in the Aragon Workers’ Health Study (AWHS) without previous cardiovascular disease (CVD) and who initiated lipid-lowering therapy. Data were collected from workplace medical examinations and administrative health databases (2010– 2018). Using cluster analysis, we identified distinct patient profiles based on persistence with therapy and lifestyle. We then compared characteristics, morbidity, and healthcare utilization across clusters. Participants were aggregated into four clusters based on persistence with therapy, smoking status, adherence to Mediterranean diet, and physical activity. In cluster 1 (n = 113), comprising those with a healthiest lifestyle (14.2% smokers, 84.0% with medium-high adherence to Mediterranean diet, high physical activity), 16.8% were persistent. In cluster 3 (n = 108), comprising patients with the least healthy lifestyle (100% smokers, poor adherence to the Mediterranean diet, low level of physical activity), all were non-persistent. Clusters 2 (n = 150) and 4 (n = 146) both comprised patients with intermediate lifestyle be-haviors, but differed in terms of persistence (100 and 0%, respectively). Compared with other clusters, the burden of morbidity, cardiovascular score, and healthcare utilization were lower in cluster 1. The healthy adherer effect was only observed in new lipid-lowering drug users of certain profiles. Furthermore, we found that differences in adherence to lifestyle and medication recommendations for CVD prevention influenced morbidity burden and healthcare utilization. 000101640 536__ $$9info:eu-repo/grantAgreement/ES/ISCIII-FEDER-FIS/PI17-01704 000101640 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/ 000101640 590__ $$a6.706$$b2021 000101640 592__ $$a1.287$$b2021 000101640 594__ $$a7.9$$b2021 000101640 591__ $$aNUTRITION & DIETETICS$$b15 / 90 = 0.167$$c2021$$dQ1$$eT1 000101640 593__ $$aNutrition and Dietetics$$c2021$$dQ1 000101640 593__ $$aFood Science$$c2021$$dQ1 000101640 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion 000101640 700__ $$0(orcid)0000-0002-6671-5661$$aRabanaque, María José$$uUniversidad de Zaragoza 000101640 700__ $$0(orcid)0000-0003-1647-3462$$aMaldonado, Lina$$uUniversidad de Zaragoza 000101640 700__ $$0(orcid)0000-0003-0604-5042$$aMoreno-Franco, Belén$$uUniversidad de Zaragoza 000101640 700__ $$aChaure-Pardos, Armando 000101640 700__ $$0(orcid)0000-0001-7587-9716$$aLallana, María Jesús 000101640 700__ $$aRodrigo, María Pilar 000101640 700__ $$0(orcid)0000-0001-7293-701X$$aAguilar-Palacio, Isabel$$uUniversidad de Zaragoza 000101640 7102_ $$14014$$2623$$aUniversidad de Zaragoza$$bDpto. Economía Aplicada$$cÁrea Métodos Cuant.Econ.Empres 000101640 7102_ $$11011$$2615$$aUniversidad de Zaragoza$$bDpto. Microb.Ped.Radio.Sal.Pú.$$cÁrea Medic.Prevent.Salud Públ. 000101640 773__ $$g13, 3 (2021), 723 [14 pp.]$$pNutrients$$tNutrients$$x2072-6643 000101640 8564_ $$s691209$$uhttps://zaguan.unizar.es/record/101640/files/texto_completo.pdf$$yVersión publicada 000101640 8564_ $$s2745501$$uhttps://zaguan.unizar.es/record/101640/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada 000101640 909CO $$ooai:zaguan.unizar.es:101640$$particulos$$pdriver 000101640 951__ $$a2023-05-18-14:32:21 000101640 980__ $$aARTICLE