000101641 001__ 101641
000101641 005__ 20230519145441.0
000101641 0247_ $$2doi$$a10.3390/polym13050684
000101641 0248_ $$2sideral$$a124115
000101641 037__ $$aART-2021-124115
000101641 041__ $$aeng
000101641 100__ $$0(orcid)0000-0002-8677-3316$$aAbad, Miriam$$uUniversidad de Zaragoza
000101641 245__ $$aSupramolecular functionalizable linear–dendritic block copolymers for the preparation of nanocarriers by microfluidics
000101641 260__ $$c2021
000101641 5060_ $$aAccess copy available to the general public$$fUnrestricted
000101641 5203_ $$aHybrid linear–dendritic block copolymers (LDBCs) having dendrons with a precise number of peripheral groups that are able to supramolecular bind functional moieties are challenging materials as versatile polymeric platforms for the preparation of functional polymeric nanocarriers. PEG2k-b-dxDAP LDBCs that are based on polyethylene glycol (PEG) as hydrophilic blocks and dendrons derived from bis-MPA having 2, 6-diacylaminopyridine (DAP) units have been efficiently synthesized by the click coupling of preformed blocks, as was demonstrated by spectroscopic techniques and mass spectrometry. Self-assembly ability was first checked by nanoprecipitation. A re-producible and fast synthesis of aggregates was accomplished by microfluidics optimizing the total flow rate and phase ratio to achieve spherical micelles and/or vesicles depending on dendron generation and experimental parameters. The morphology and size of the self-assemblies were studied by TEM, Cryogenic Transmission Electron Microscopy (cryo-TEM), and Dynamic Light Scattering (DLS). The cytotoxicity of aggregates synthesized by microfluidics and the influence on apoptosis and cell cycle evaluation was studied on four cell lines. The self-assemblies are not cytotoxic at doses below 0.4 mg mL–1. Supramolecular functionalization using thymine derivatives was explored for reversibly cross-linking the hydrophobic blocks. The results open new possibilities for their use as drug nanocarriers with a dynamic cross-linking to improve nanocarrier stability but without hindering disassembly to release molecular cargoes.
000101641 536__ $$9info:eu-repo/grantAgreement/ES/DGA-FEDER/E47-17R$$9info:eu-repo/grantAgreement/ES/ISCIII-IIS/MS19-00092$$9info:eu-repo/grantAgreement/ES/MICINN/RTI2018-099019-A-I00$$9info:eu-repo/grantAgreement/ES/MINECO/MAT2017-84838-P
000101641 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000101641 590__ $$a4.967$$b2021
000101641 592__ $$a0.726$$b2021
000101641 594__ $$a5.7$$b2021
000101641 591__ $$aPOLYMER SCIENCE$$b16 / 90 = 0.178$$c2021$$dQ1$$eT1
000101641 593__ $$aPolymers and Plastics$$c2021$$dQ1
000101641 593__ $$aChemistry (miscellaneous)$$c2021$$dQ1
000101641 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000101641 700__ $$0(orcid)0000-0003-1807-2072$$aMartínez-Bueno, Alejandro
000101641 700__ $$0(orcid)0000-0003-2293-363X$$aMendoza, Gracia
000101641 700__ $$0(orcid)0000-0003-3165-0156$$aArruebo, Manuel$$uUniversidad de Zaragoza
000101641 700__ $$0(orcid)0000-0002-0922-5615$$aOriol, Luis$$uUniversidad de Zaragoza
000101641 700__ $$0(orcid)0000-0002-6873-5244$$aSebastián, Víctor$$uUniversidad de Zaragoza
000101641 700__ $$0(orcid)0000-0001-5556-2172$$aPiñol, Milagros$$uUniversidad de Zaragoza
000101641 7102_ $$15005$$2555$$aUniversidad de Zaragoza$$bDpto. Ing.Quím.Tecnol.Med.Amb.$$cÁrea Ingeniería Química
000101641 7102_ $$12013$$2765$$aUniversidad de Zaragoza$$bDpto. Química Orgánica$$cÁrea Química Orgánica
000101641 773__ $$g13, 5 (2021), 684 [27 pp.]$$pPolymers (Basel)$$tPolymers$$x2073-4360
000101641 8564_ $$s10830057$$uhttps://zaguan.unizar.es/record/101641/files/texto_completo.pdf$$yVersión publicada
000101641 8564_ $$s2751824$$uhttps://zaguan.unizar.es/record/101641/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000101641 909CO $$ooai:zaguan.unizar.es:101641$$particulos$$pdriver
000101641 951__ $$a2023-05-18-14:32:25
000101641 980__ $$aARTICLE