000102086 001__ 102086
000102086 005__ 20220426091137.0
000102086 0247_ $$2doi$$a10.1016/j.aller.2020.03.009
000102086 0248_ $$2sideral$$a118197
000102086 037__ $$aART-2020-118197
000102086 041__ $$aeng
000102086 100__ $$aAgulló-García, A.
000102086 245__ $$aClinical and anatomopathological features of eosinophilic oesophagitis in children and adults
000102086 260__ $$c2020
000102086 5060_ $$aAccess copy available to the general public$$fUnrestricted
000102086 5203_ $$aIntroduction: Eosinophilic oesophagitis (EoE) is a chronic clinical-pathological disorder with an immunological basis characterised by symptoms of oesophageal dysfunction and, histologically, eosinophilic inflammation.
Objective: To evaluate the clinical characteristics and differences in children and adults diagnosed with EoE in a tertiary level hospital.
Method: Descriptive, retrospective and cross-sectional study. We randomly selected 40 children and 40 adults diagnosed with EoE between 2009 and 2016. The patient characteristics were analysed by means of epidemiological, clinical, diagnostic and therapeutic variables.
Results: The average age at diagnosis was 10 years (children) and 34 years (adults), with a higher frequency in males. The majority were sensitised to aeroallergens (77.5% children vs. 82.5% adults) and foods (75% children vs. 82.5% adults). Statistically significant differences were detected in sensitisation to fruits (p = 0.007) and grains (p < 0.001). Differences were observed in impaction (22.5% children vs. 82.5% adults), dysphagia (42.5% children vs. 77.5% adults) and abdominal pain (25% children vs. 7.5% adults). Endoscopy showed that children had a higher frequency of exudates (92.5%) and adults, trachealisation (50% vs. 5%) and stenosis (17.5% vs. 2.5%). Statistically significant differences were found in treatment with topical corticosteroids (30% children vs. 77.5% adults), with a variable positive response. 77.5% of the patients received elimination diets.
Conclusions: Statistically significant differences were observed between the paediatric and adult populations in the food sensitisation profiles, clinical manifestations, endoscopic findings and treatments received. This is a complex pathology that calls for a multidisciplinary team and would require new non-invasive techniques to facilitate its management.
000102086 540__ $$9info:eu-repo/semantics/openAccess$$aAll rights reserved$$uhttp://www.europeana.eu/rights/rr-f/
000102086 590__ $$a1.667$$b2020
000102086 591__ $$aIMMUNOLOGY$$b150 / 162 = 0.926$$c2020$$dQ4$$eT3
000102086 591__ $$aALLERGY$$b24 / 28 = 0.857$$c2020$$dQ4$$eT3
000102086 592__ $$a0.482$$b2020
000102086 593__ $$aImmunology$$c2020$$dQ3
000102086 593__ $$aPulmonary and Respiratory Medicine$$c2020$$dQ3
000102086 593__ $$aMedicine (miscellaneous)$$c2020$$dQ3
000102086 593__ $$aImmunology and Allergy$$c2020$$dQ3
000102086 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/acceptedVersion
000102086 700__ $$aCubero, J.L.
000102086 700__ $$aLezaun, A.
000102086 700__ $$aBoné, J.
000102086 700__ $$aGuallar, I.
000102086 700__ $$0(orcid)0000-0001-8959-6784$$aColás, C.$$uUniversidad de Zaragoza
000102086 7102_ $$11007$$2610$$aUniversidad de Zaragoza$$bDpto. Medicina, Psiqu. y Derm.$$cArea Medicina
000102086 773__ $$g48, 6 (2020), 560-567$$pAllergol. immunopathol.$$tAllergologia et Immunopathologia$$x0301-0546
000102086 8564_ $$s324657$$uhttps://zaguan.unizar.es/record/102086/files/texto_completo.pdf$$yPostprint
000102086 8564_ $$s2003961$$uhttps://zaguan.unizar.es/record/102086/files/texto_completo.jpg?subformat=icon$$xicon$$yPostprint
000102086 909CO $$ooai:zaguan.unizar.es:102086$$particulos$$pdriver
000102086 951__ $$a2022-04-26-08:54:21
000102086 980__ $$aARTICLE