000102092 001__ 102092
000102092 005__ 20250117145308.0
000102092 0247_ $$2doi$$a10.1021/acs.inorgchem.0c00813
000102092 0248_ $$2sideral$$a118219
000102092 037__ $$aART-2020-118219
000102092 041__ $$aeng
000102092 100__ $$aLuengo, Andrés
000102092 245__ $$aLuminescent Re(I)/Au(I) Species As Selective Anticancer Agents for HeLa Cells
000102092 260__ $$c2020
000102092 5060_ $$aAccess copy available to the general public$$fUnrestricted
000102092 5203_ $$aA series of neutral and cationic heterotrimetallic complexes of the type fac-[Re(CO)3(bipy(CC)2-(AuL)2)X]n, where bipy(CC)2 is 4, 4'-alkynyl-2, 2'-bipyridine; L is either triphenylphosphine (PPh3), [1, 3-bis(2, 6-diisopropylphenyl)-imidazol-2-ylidene] (IPr), or tert-butyl isocyanide (CNtBu); and X is a chloride (n = 0) or acetonitrile (n = 1), were synthesized and characterized together with their Re(I) precursors, i.e., fac-[Re(CO)3(bipy(CC)2)X]n. X-ray diffraction of complexes 1, 3, and 6 corroborated the expected octahedral and linear distribution of the ligands along the Re(I) and Au(I) centers, respectively. Luminescent studies showed that all the complexes displayed a broad emission band centered between 565 and 680 nm, corresponding to a 3MLCT from the Re(I) to the diimine derivative. The presence of the gold fragment coordinated to the diimine ligand shifted in all cases the emission maxima toward higher energies. Such an emission difference could be potentially used for assessing the precise moment of interaction of the probe with the biological target if the gold fragment is implicated. Antiproliferative studies in cancer cells, A549 (lung cancer) and HeLa (cervix cancer), showed a generalized selectivity toward HeLa cells for those heterotrimetallic species incubated at longer times (72 vs 24 h). ICP-MS spectrometry revealed the greater cell internalization of cationic vs neutral species. Preliminary fluorescence microscopy experiments showed a different behavior of the complexes in HeLa and A549 cell lines. Whereas the complexes in A549 were randomly distributed in the outside of the cell, those incubated with HeLa cells were located close to the cellular membrane, suggesting some type of interaction, and possibly explaining their cellular selectivity when it comes to the antiproliferative activity displayed in the different cell lines.
000102092 536__ $$9info:eu-repo/grantAgreement/ES/DGA-FSE/E07-20R$$9info:eu-repo/grantAgreement/ES/MCIU/RED2018-102471-T$$9info:eu-repo/grantAgreement/ES/MCIU/RTI2018-097836-J-I00$$9info:eu-repo/grantAgreement/ES/MINECO-FEDER/CTQ2016-75816-C2-1-P
000102092 540__ $$9info:eu-repo/semantics/openAccess$$aAll rights reserved$$uhttp://www.europeana.eu/rights/rr-f/
000102092 590__ $$a5.165$$b2020
000102092 591__ $$aCHEMISTRY, INORGANIC & NUCLEAR$$b5 / 45 = 0.111$$c2020$$dQ1$$eT1
000102092 592__ $$a1.348$$b2020
000102092 593__ $$aChemistry (miscellaneous)$$c2020$$dQ1
000102092 593__ $$aPhysical and Theoretical Chemistry$$c2020$$dQ1
000102092 593__ $$aInorganic Chemistry$$c2020$$dQ1
000102092 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/acceptedVersion
000102092 700__ $$0(orcid)0000-0001-5201-0874$$aRedrado, Marta
000102092 700__ $$0(orcid)0000-0002-2315-9079$$aMarzo, Isabel$$uUniversidad de Zaragoza
000102092 700__ $$0(orcid)0000-0002-1218-7218$$aFernández-Moreira, Vanesa$$uUniversidad de Zaragoza
000102092 700__ $$0(orcid)0000-0003-0553-0695$$aGimeno, M.Concepción$$uUniversidad de Zaragoza
000102092 7102_ $$12010$$2760$$aUniversidad de Zaragoza$$bDpto. Química Inorgánica$$cÁrea Química Inorgánica
000102092 7102_ $$11002$$2050$$aUniversidad de Zaragoza$$bDpto. Bioq.Biolog.Mol. Celular$$cÁrea Biología Celular
000102092 773__ $$g59, 13 (2020), 8960–8970$$pInorg. chem.$$tInorganic Chemistry$$x0020-1669
000102092 8564_ $$s1037461$$uhttps://zaguan.unizar.es/record/102092/files/texto_completo.pdf$$yPostprint
000102092 8564_ $$s2820609$$uhttps://zaguan.unizar.es/record/102092/files/texto_completo.jpg?subformat=icon$$xicon$$yPostprint
000102092 909CO $$ooai:zaguan.unizar.es:102092$$particulos$$pdriver
000102092 951__ $$a2025-01-17-14:45:00
000102092 980__ $$aARTICLE